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Pleiotrophin (PTN) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844985

Background: Human Pleiotrophin (PTN) also called HARP (Heparin affin regulatory peptide) is a new member of the heparin-binding neurotrophic factor family. PTN (Pleiotrophin) and MK (midkine) are structural homologs, and are highly conserved among species.… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Pleiotrophin (PTN), Recombinant Protein
Full Product Name
Pleiotrophin (PTN), human recombinant
Product Gene Name
PTN recombinant protein
Product Synonym Names
PTN; Heparin Affin Regulatory Protein; HARP; Heparin-binding growth factor-8; HBGF-8; Osteoblast-Specific Factor-1; OSF-1; Heparin-binding growth-associated molecule; HB-GAM; HBNF-1 Heparin-binding brain mitogen; Heparin-binding neurite outgrowth-promoting factor 1; HBBM; NEGF1.
Host
E Coli
Form/Format
Lyophilized from 0.4X PBS, pH 7.2
Appearance: Lyophilized protein
Purity/Purification
>=98%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
20.6 kDa
OMIM
162095
3D Structure
ModBase 3D Structure for P21246
Solubility/Reconstitution Instructions
Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4 degree C for 1 week or -20 degree C for future use.
Endotoxin Level
<0.1 ng/mug
Handling
Centrifuge the vial prior to opening.
Applications Tested/Suitable for PTN recombinant protein
SDS-PAGE; HPLC

Other Notes

Small volumes of PTN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTN purchase

MBS844985 is a recombinant protein targeting PTN. Also known as Pleiotrophin (PTN), human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PTN. It may not necessarily be applicable to this product.

NCBI GI #
4506281
NCBI GeneID
5764
NCBI Accession #
NP_002816.1
UniProt Primary Accession #
P21246
UniProt Secondary Accession #
Q5U0B0; Q6ICQ5; Q9UCC6
UniProt Related Accession #
P21246
GenBank Nucleotide #
NM_002825.5
NCBI Official Full Name
pleiotrophin
NCBI Official Synonym Full Names
pleiotrophin
NCBI Official Symbol
PTN
NCBI Official Synonym Symbols
HARP; HBNF; HBGF8; NEGF1
UniProt Protein Name
Pleiotrophin
UniProt Synonym Protein Names
Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Heparin-binding growth-associated molecule; HB-GAM; Heparin-binding neurite outgrowth-promoting factor 1; HBNF-1; Osteoblast-specific factor 1; OSF-1
Protein Family
Pleiotrophin
UniProt Gene Name
PTN
UniProt Synonym Gene Names
HBNF1; NEGF1; PTN; HBBM; HBGF-8; HB-GAM; HBNF-1; OSF-1
UniProt Entry Name
PTN_HUMAN
NCBI Protein Information
pleiotrophin

UniProt Comments for PTN

PTN: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. Belongs to the pleiotrophin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: extracellular space; endoplasmic reticulum

Molecular Function: heparin binding; growth factor activity; protein phosphatase inhibitor activity

Biological Process: nervous system development; positive regulation of cell division; positive regulation of cell proliferation; negative regulation of catalytic activity; learning; transmembrane receptor protein tyrosine phosphatase signaling pathway; bone mineralization
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Research Articles on PTN

1. PTN expression in glioma was higher than in paratumor tissues. Overexpression was associated with the WHO grade, low Karnofsky score, time to recurrence, and poor survival. Co-expression of midkine and PTN had a worse prognosis than either alone.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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