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Cathepsin K (CTSK) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845329

Background: Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Cathepsin K (CTSK), Active Protein
Full Product Name
Cathepsin K, Active, mouse recombinant
Product Gene Name
CTSK active protein
Product Synonym Names
CTSK; CTSO; CTSO3
Host
E Coli
Form/Format
0.5 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.
Appearance: Liquid
Purity/Purification
>=90%
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
At -80 degree C
Shelf Life: 6 months
Molecular Weight
23.4 kDa (115-329 aa)
3D Structure
ModBase 3D Structure for P55097
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Activity (Specifications/test method)
The Cathepsin K is fully active as seen from its ability to cleave Cathepsin K-specific fluorescent substrate using the Cathepsin K Activity assay kit.
Biological Activity
The specific activity is >1000 mU/mg (1U = 1 umole/min/mg) as measured by Cathepsin K Activity Assay Kit
Results
The specific activity is >1000 mU/mg (1U = 1 umole/min/mg) as measured by Cathepsin K Activity Assay Kit
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for CTSK active protein

Apoptosis; Non-Caspase Proteases; Cathepsin; Cathepsin EnzymesProteins and Enzymes; Proteases; CathepsinsProteins and Enzymes; Proteins and Enzymes (A-Z) Proteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins & Enzyme
Applications Tested/Suitable for CTSK active protein
SDS-PAGE

Testing Data of CTSK active protein

CTSK Active Protein – Cat# MBS845329

Other Notes

Small volumes of CTSK active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTSK purchase

MBS845329 is an active protein targeting CTSK. Also known as Cathepsin K, Active, mouse recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CTSK. It may not necessarily be applicable to this product.

NCBI GI #
31982433
NCBI GeneID
13038
NCBI Accession #
NP_031828.2
UniProt Primary Accession #
P55097
UniProt Secondary Accession #
O88718
UniProt Related Accession #
P55097
GenBank Nucleotide #
NM_007802.4
NCBI Official Full Name
cathepsin K
NCBI Official Synonym Full Names
cathepsin K
NCBI Official Symbol
Ctsk
NCBI Official Synonym Symbols
catK; Ms10q; MMS10-Q; AI323530
UniProt Protein Name
Cathepsin K
Protein Family
Cathepsin
UniProt Gene Name
Ctsk
UniProt Entry Name
CATK_MOUSE
NCBI Protein Information
cathepsin K

UniProt Comments for CTSK

CTSK: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Defects in CTSK are the cause of pycnodysostosis (PKND). PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Belongs to the peptidase C1 family.

Protein type: EC 3.4.22.38; Protease

Cellular Component: extracellular space; lysosome; cytoplasm

Molecular Function: collagen binding; peptidase activity; proteoglycan binding; hydrolase activity; fibronectin binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity

Biological Process: collagen catabolic process; proteolysis involved in cellular protein catabolic process; proteolysis; bone resorption
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Research Articles on CTSK

1. Data (including data from studies in knockout/transgenic mice) suggest that Ctsk is involved in inflammatory response and bone resorption in both rheumatoid arthritis and periodontitis; thus, Ctsk appears to play a role in osteoimmune responses.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CTSK active protein

 Reference Product  PubMed Publications
 Mmp13 active protein  >9 publications with CTSK and Mmp13
 Mmp3 active protein  >5 publications with CTSK and Mmp3
 Mmp7 active protein  >4 publications with CTSK and Mmp7
 Tlr9 active protein  >3 publications with CTSK and Tlr9
 Tlr3 active protein  >1 publications with CTSK and Tlr3
 Col18a1 active protein  >1 publications with CTSK and Col18a1
 Tlr7 active protein  >1 publications with CTSK and Tlr7

Diseases associated with CTSK active protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >62 publications with CTSK and Necrosis
 Disease Models, Animal Antibodies  >58 publications with CTSK and Disease Models, Animal
 Pycnodysostosis Antibodies  >54 publications with CTSK and Pycnodysostosis
 Inflammation Antibodies  >49 publications with CTSK and Inflammation
 Cardiovascular Diseases Antibodies  >32 publications with CTSK and Cardiovascular Diseases
 Atherosclerosis Antibodies  >22 publications with CTSK and Atherosclerosis
 Lung Diseases Antibodies  >22 publications with CTSK and Lung Diseases
 Nervous System Diseases Antibodies  >21 publications with CTSK and Nervous System Diseases
 Fibrosis Antibodies  >16 publications with CTSK and Fibrosis
 Congenital Abnormalities Antibodies  >15 publications with CTSK and Congenital Abnormalities

Organs/Tissues associated with CTSK active protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >520 publications with CTSK and Bone
 Joint Antibodies  >61 publications with CTSK and Joint
 Lung Antibodies  >41 publications with CTSK and Lung
 Liver Antibodies  >22 publications with CTSK and Liver
 Skin Antibodies  >17 publications with CTSK and Skin
 Heart Antibodies  >16 publications with CTSK and Heart
 Kidney Antibodies  >16 publications with CTSK and Kidney
 Spleen Antibodies  >14 publications with CTSK and Spleen
 Prostate Antibodies  >13 publications with CTSK and Prostate
 Embryonic Tissue Antibodies  >13 publications with CTSK and Embryonic Tissue
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