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AKR1A1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9404111

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in… More details

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Product Overview

Online Datasheet in PDF
Product Name
AKR1A1, Polyclonal Antibody
Full Product Name
AKR1A1 Antibody
Product Gene Name
anti-AKR1A1 antibody
Product Synonym Names
AKR1A1; ALDR1; ALR; ARM; DD3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Antibodies were purified by affinity purification using immunogen.
Concentration
1.0 mg/ml (lot specific)
Specificity
The antibody detects endogenous level of total AKR1A1 protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
36,573 Da
OMIM
103830
3D Structure
ModBase 3D Structure for P14550
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein of human AKR1A1.
Target Name
AKR1A1

Product Categories/Family for anti-AKR1A1 antibody

Total protein Ab
Applications Tested/Suitable for anti-AKR1A1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-AKR1A1 antibody
Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:100

Western Blot (WB) of anti-AKR1A1 antibody

Western blot analysis of Y79 cell and Jurkat cell lysate using AKR1A1 antibody.
Rabbit Anti-AKR1A1 Polyclonal Antibody – Cat# MBS9404111

Immunohistochemistry (IHC) of anti-AKR1A1 antibody

Immunohistochemical analysis of paraffin-embedded human thyroid cancer using AKR1A1 antibody at dilution of 1:400 (200x lens).
Rabbit Anti-AKR1A1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9404111

Immunohistochemistry (IHC) of anti-AKR1A1 antibody

Immunohistochemical analysis of paraffin-embedded human endometrial cancer using AKR1A1 antibody at dilution of 1:400 (200x lens).
Rabbit Anti-AKR1A1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9404111

Other Notes

Small volumes of anti-AKR1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKR1A1 purchase

MBS9404111 is an antibody targeting AKR1A1. Also known as AKR1A1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AKR1A1. It may not necessarily be applicable to this product.

NCBI GI #
320202988
NCBI GeneID
10327
NCBI Accession #
NP_001189342.1
UniProt Primary Accession #
P14550
UniProt Secondary Accession #
Q6IAZ4; A8KAL8; D3DQ04
UniProt Related Accession #
P14550
GenBank Nucleotide #
NM_001202413.1
NCBI Official Full Name
alcohol dehydrogenase
NCBI Official Synonym Full Names
aldo-keto reductase family 1, member A1 (aldehyde reductase)
NCBI Official Symbol
AKR1A1
NCBI Official Synonym Symbols
ALR; ARM; DD3; ALDR1; HEL-S-6
UniProt Protein Name
Alcohol dehydrogenase [NADP(+)]
UniProt Synonym Protein Names
Aldehyde reductase; Aldo-keto reductase family 1 member A1
Protein Family
Alcohol dehydrogenase
UniProt Gene Name
AKR1A1
UniProt Synonym Gene Names
ALDR1; ALR
UniProt Entry Name
AK1A1_HUMAN
NCBI Protein Information
alcohol dehydrogenase [NADP(+)]

UniProt Comments for AKR1A1

AKR1A1: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Belongs to the aldo/keto reductase family.

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lipid Metabolism - glycerolipid; EC 1.1.1.2; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p33-p32

Cellular Component: extracellular space; apical plasma membrane; cytosol

Molecular Function: L-glucuronate reductase activity; electron carrier activity; aldehyde reductase activity

Biological Process: aldehyde catabolic process; L-ascorbic acid biosynthetic process; D-glucuronate catabolic process; glucose metabolic process; aldehyde metabolic process
Show more

Research Articles on AKR1A1

1. prostaglandin F synthase activity of human and bovine aldo-keto reductases

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AKR1A1 antibody

 Reference Product  PubMed Publications
 ALDH1A3 antibody  >1 publications with AKR1A1 and ALDH1A3

Pathways associated with anti-AKR1A1 antibody

 Products by Pathway  Pathway Diagram
 Benzo(a)pyrene Metabolism Pathway antibodies  Benzo(a)pyrene Metabolism Pathway Diagram
 Biosynthesis Of Antibiotics Pathway antibodies  Biosynthesis Of Antibiotics Pathway Diagram
 Degradation Of Aromatic Compounds Pathway antibodies  Degradation Of Aromatic Compounds Pathway Diagram
 Degradation Of Aromatic Compounds Pathway antibodies  Degradation Of Aromatic Compounds Pathway Diagram
 Glucuronate Pathway (uronate Pathway) antibodies  Glucuronate Pathway (uronate Pathway) Diagram
 Glucuronate Pathway (uronate Pathway) antibodies  Glucuronate Pathway (uronate Pathway) Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram

Diseases associated with anti-AKR1A1 antibody

 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >3 publications with AKR1A1 and Lung Neoplasms
 Lung Injury Antibodies  >2 publications with AKR1A1 and Lung Injury
 Inflammation Antibodies  >2 publications with AKR1A1 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >1 publications with AKR1A1 and Cell Transformation, Neoplastic
 Neurobehavioral Manifestations Antibodies  >1 publications with AKR1A1 and Neurobehavioral Manifestations
 Disease Models, Animal Antibodies  >1 publications with AKR1A1 and Disease Models, Animal
 Acute Kidney Injury Antibodies  >1 publications with AKR1A1 and Acute Kidney Injury
 Kidney Diseases Antibodies  >1 publications with AKR1A1 and Kidney Diseases

Organs/Tissues associated with anti-AKR1A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >11 publications with AKR1A1 and Liver
 Lung Antibodies  >9 publications with AKR1A1 and Lung
 Kidney Antibodies  >5 publications with AKR1A1 and Kidney
 Blood Antibodies  >5 publications with AKR1A1 and Blood
 Prostate Antibodies  >3 publications with AKR1A1 and Prostate
 Muscle Antibodies  >3 publications with AKR1A1 and Muscle
 Intestine Antibodies  >2 publications with AKR1A1 and Intestine
 Heart Antibodies  >2 publications with AKR1A1 and Heart
 Testis Antibodies  >2 publications with AKR1A1 and Testis
 Brain Antibodies  >2 publications with AKR1A1 and Brain
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