Human Recombinant AKR7A3 Active Protein – Cat# MBS845376

AKR7A3 Human Recombinant Active Protein

Name: AKR7A3 Active Protein; Human Recombinant; MyBioSource
Brand: MyBioSource
SKU: MBS845376
Price: 560 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845376

Background: AKR7A3, is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. It takes part in the detoxification of aldehydes and ketones. AKR7A3 reduces the dialdehyde protein-binding form of aflatoxin B1… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

AKR7A3, Active Protein

Full Product Name

Human Recombinant AKR7A3

Product Gene Name

AKR7A3 active protein

Product Synonym Names

Aldo-keto reductase family 7; member A 3; Aflatoxin B1 aldehyde reductase member 3; AFB1 aldehyde reductase 2(AFAR2).; Human Recombinant AKR7A3

Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSELE SRQLSRARPA TVLGAMEMGR RMDAPTSAAV TRAFLERGHT EIDTAFVYSE GQSETILGGL GLRLGGSDCR VKIDTKAIPL FGNSLKPDSL RFQLETSLKR LQCPRVDLFY LHMPDHSTPV EETLRACHQL HQEGKFVELG LSNYAAWEVA EICTLCKSNG WILPTVYQGM YNAITRQVET ELFPCLRHFG LRFYAFNPLA GGLLTGKYKY EDKDGKQPVG RFFGNTWAEM YRNRYWKEHH FEGIALVEKA LQAAYGASAP SMTSATLRWM YHHSQLQGAH GDAVILGMSS LEQLEQNLAA AEEGPLEPAV VDAFNQAWHL VAHECPNYFR

Host

E Coli

Form/Format

0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 10% glycerol.
Appearance: Liquid

Purity/Purification

>=95%

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

41.6 kDa

OMIM

608477

3D Structure

ModBase 3D Structure for O95154

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is approximately > 0.1 units/mg

Unit Definition

Specific activity is approximately > 0.1 units/mg. Enzymatic activity was confirmed by measuring the amount of enzyme catalyzing the oxidation of 1 micromole NADPH per minute at 25 degree C. Specific activity was expressed as units/mg protein.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for AKR7A3 active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)

Applications Tested/Suitable for AKR7A3 active protein

SDS-PAGE

Other Notes

Small volumes of AKR7A3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKR7A3 purchase

MBS845376 is an active protein targeting AKR7A3. Also known as Human Recombinant AKR7A3. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for AKR7A3. It may not necessarily be applicable to this product.

NCBI GI #

41152114

NCBI GeneID

22977

NCBI Accession #

NP_036199.2

UniProt Primary Accession #

O95154

UniProt Secondary Accession #

Q86SR4; Q8IVN6; Q8N5V6; Q8TAX1; Q9NUC3

UniProt Related Accession #

O95154

GenBank Nucleotide #

NM_012067.2

NCBI Official Full Name

aflatoxin B1 aldehyde reductase member 3

NCBI Official Synonym Full Names

aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)

NCBI Official Symbol

AKR7A3

NCBI Official Synonym Symbols

AFAR2

UniProt Protein Name

Aflatoxin B1 aldehyde reductase member 3

UniProt Synonym Protein Names

AFB1 aldehyde reductase 2; AFB1-AR 2

Protein Family

Aflatoxin B1 aldehyde reductase

UniProt Gene Name

AKR7A3

UniProt Synonym Gene Names

AFAR2; AFB1-AR 2

UniProt Entry Name

ARK73_HUMAN

NCBI Protein Information

aflatoxin B1 aldehyde reductase member 3

NCBI Summary for AKR7A3

Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]

UniProt Comments for AKR7A3

AKR7A3: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.

Protein type: EC 1.-.-.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: cytosol

Molecular Function: electron carrier activity; aldo-keto reductase activity

Biological Process: xenobiotic metabolic process; aldehyde metabolic process

Research Articles on AKR7A3

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AKR7A3 active protein

Reference Product	PubMed Publications
AKR7A2 active protein	>3 publications with AKR7A3 and AKR7A2
AKR1A1 active protein	>1 publications with AKR7A3 and AKR1A1

Pathways associated with AKR7A3 active protein

Products by Pathway	Pathway Diagram
Aflatoxin B1 Metabolism Pathway antibodies	Aflatoxin B1 Metabolism Pathway Diagram
Aflatoxin Activation And Detoxification Pathway antibodies	Aflatoxin Activation And Detoxification Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies	Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies	Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
Metapathway Biotransformation antibodies	Metapathway Biotransformation Diagram

Diseases associated with AKR7A3 active protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>10 publications with AKR7A3 and Liver Diseases
Liver Neoplasms Antibodies	>8 publications with AKR7A3 and Liver Neoplasms
Liver Neoplasms, Experimental Antibodies	>7 publications with AKR7A3 and Liver Neoplasms, Experimental
Poisoning Antibodies	>2 publications with AKR7A3 and Poisoning
Drug-Related Side Effects and Adverse Reactions Antibodies	>2 publications with AKR7A3 and Drug-Related Side Effects and Adverse Reactions
Inflammation Antibodies	>2 publications with AKR7A3 and Inflammation
Drug-Induced Liver Injury Antibodies	>2 publications with AKR7A3 and Drug-Induced Liver Injury
Breast Neoplasms Antibodies	>1 publications with AKR7A3 and Breast Neoplasms
Precancerous Conditions Antibodies	>1 publications with AKR7A3 and Precancerous Conditions
Carcinoma, Hepatocellular Antibodies	>1 publications with AKR7A3 and Carcinoma, Hepatocellular

Organs/Tissues associated with AKR7A3 active protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>15 publications with AKR7A3 and Liver
Kidney Antibodies	>2 publications with AKR7A3 and Kidney
Testis Antibodies	>1 publications with AKR7A3 and Testis
Pancreas Antibodies	>1 publications with AKR7A3 and Pancreas
Stomach Antibodies	>1 publications with AKR7A3 and Stomach