Human Cellexp GPNMB Active Protein – Cat# MBS845552

Osteoactivin/GPNMB (GPNMB) Human Cellexp Active Protein

Name: GPNMB Active Protein; Osteoactivin/GPNMB; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS845552
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845552

Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN; DC-HIL and Osteoactivin (OA); which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Osteoactivin/GPNMB, Active Protein

Full Product Name

Human CellExp Osteoactivin/GPNMB; human recombinant

Product Gene Name

GPNMB active protein

Product Synonym Names

GPNMB; HGFIN; NMB; Osteoactivin

Host

HEK293 cells
Source: Human

Form/Format

Lyophilized from 0.22 mum filtered solution in PBS; pH 7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.

Purity/Purification

>=95%

Preparation and Storage

Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.

Molecular Weight

52.9 kDa

3D Structure

ModBase 3D Structure for Q96F58

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Tag Information

This protein is fused with 6× His tag at the C-terminus. The predicted N-terminus is Ala 22. DTT-reduced Protein migrates as 85-100 kDa due to glycosylation.

Endotoxin Level

<1 EU/mug by LAL method

Biological Activity

Measured by the ability of the immobilized protein to induce pro-MMP-9 secretion by NHLF human normal lung fibroblasts. The ED50 for this effect is typically 4- 16 ug/ml.

Results

ED50 for this effect is typically 4- 16 ug/ml

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in PBS; pH 7.4. Do not vortex.

Applications Tested/Suitable for GPNMB active protein

SDS-PAGE

Other Notes

Small volumes of GPNMB active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPNMB purchase

MBS845552 is an active protein targeting GPNMB. Also known as Human CellExp Osteoactivin/GPNMB; human recombinant. Host: HEK293 cells
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for GPNMB. It may not necessarily be applicable to this product.

NCBI GI #

4505405

NCBI GeneID

10457

NCBI Accession #

NP_002501.1

UniProt Primary Accession #

Q96F58

UniProt Related Accession #

Q14956

GenBank Nucleotide #

NM_002510.2

NCBI Official Full Name

transmembrane glycoprotein NMB isoform b

NCBI Official Synonym Full Names

glycoprotein nmb

NCBI Official Symbol

GPNMB

NCBI Official Synonym Symbols

NMB; HGFIN

UniProt Protein Name

GPNMB protein

UniProt Synonym Protein Names

GPNMB protein

Protein Family

Transmembrane glycoprotein

UniProt Gene Name

GPNMB

NCBI Protein Information

transmembrane glycoprotein NMB

NCBI Summary for GPNMB

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Research Articles on GPNMB

1. it may be premature to conclude associations between GPNMB rs156429 and Parkinson's disease, amyotrophic lateral sclerosis and multiple system atrophy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GPNMB active protein

Reference Product	PubMed Publications
TYRP1 active protein	>14 publications with GPNMB and TYRP1
FLCN active protein	>2 publications with GPNMB and FLCN
TREM2 active protein	>1 publications with GPNMB and TREM2
TFE3 active protein	>1 publications with GPNMB and TFE3

Diseases associated with GPNMB active protein

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>18 publications with GPNMB and Disease Models, Animal
Inflammation Antibodies	>17 publications with GPNMB and Inflammation
Breast Neoplasms Antibodies	>11 publications with GPNMB and Breast Neoplasms
Kidney Diseases Antibodies	>10 publications with GPNMB and Kidney Diseases
Liver Diseases Antibodies	>10 publications with GPNMB and Liver Diseases
Fibrosis Antibodies	>6 publications with GPNMB and Fibrosis
Cardiovascular Diseases Antibodies	>5 publications with GPNMB and Cardiovascular Diseases
Hypertension Antibodies	>5 publications with GPNMB and Hypertension
Neoplasms, Experimental Antibodies	>5 publications with GPNMB and Neoplasms, Experimental
Necrosis Antibodies	>4 publications with GPNMB and Necrosis

Organs/Tissues associated with GPNMB active protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>51 publications with GPNMB and Eye
Blood Antibodies	>39 publications with GPNMB and Blood
Bone Antibodies	>32 publications with GPNMB and Bone
Kidney Antibodies	>15 publications with GPNMB and Kidney
Nerve Antibodies	>14 publications with GPNMB and Nerve
Brain Antibodies	>14 publications with GPNMB and Brain
Liver Antibodies	>13 publications with GPNMB and Liver
Skin Antibodies	>10 publications with GPNMB and Skin
Muscle Antibodies	>10 publications with GPNMB and Muscle
Lung Antibodies	>8 publications with GPNMB and Lung