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CD38 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6009839

CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. More details

$895 / 0.2 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
CD38, Polyclonal Antibody
Full Product Name
CD38, CT (CD38, ADP-ribosyl cyclase 1, Cyclic ADP-ribose hydrolase 1, T10, CD38)
Product Gene Name
anti-CD38 antibody
Product Synonym Names
Anti -CD38, CT (CD38, ADP-ribosyl cyclase 1, Cyclic ADP-ribose hydrolase 1, T10, CD38)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Purified
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
34,328 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (15779921..15850706). Location: 4p15
OMIM
107270
3D Structure
ModBase 3D Structure for P28907
Immunogen
CD38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253~283 amino acids from the C-terminal region of human CD38.

Product Categories/Family for anti-CD38 antibody

Antibodies; Abs to CD Markers
Applications Tested/Suitable for anti-CD38 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes for anti-CD38 antibody
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100
Immunohistochemistry: 1:50-100
Immunofluorescence 1:10-50
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-CD38 antibody

Western blot analysis of CD38 antibody (C-term) in HepG2 cell line lysates (35ug/lane). CD38 (arrow) was detected using the purified Pab.
Rabbit Anti-CD38 Polyclonal Antibody – Cat# MBS6009839

Immunohistochemistry (IHC) of anti-CD38 antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma with CD38 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CD38 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6009839

Immunofluorescence (IF) of anti-CD38 antibody

Immunofluorescence analysis of CD38 Antibody (C-term) with paraffin-embedded human hepatocarcinoma tissue . 0.05 mg/ml primary antibody was followed by FITC-conjugated goat anti-rabbit lgG (whole molecule). FITC emits green fluorescence.Red counterstaining is PI.
Rabbit Anti-CD38 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6009839

Flow Cytometry (FC/FACS) of anti-CD38 antibody

Flow cytometric analysis of HepG2 cells using CD38 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CD38 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6009839

Western Blot (WB) of anti-CD38 antibody

Western blot analysis of CD38 (arrow) using rabbit polyclonal CD38 Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CD38 gene.
Rabbit Anti-CD38 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6009839

Other Notes

Small volumes of anti-CD38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD38 purchase

MBS6009839 is an antibody targeting CD38. Also known as CD38, CT (CD38, ADP-ribosyl cyclase 1, Cyclic ADP-ribose hydrolase 1, T10, CD38). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD38. It may not necessarily be applicable to this product.

NCBI GI #
1911103
NCBI GeneID
952
NCBI Accession #
BAA18966.1
UniProt Primary Accession #
P28907
UniProt Secondary Accession #
O00121; O00122; Q96HY4
UniProt Related Accession #
P28907
NCBI Official Full Name
CD38
NCBI Official Synonym Full Names
CD38 molecule
NCBI Official Symbol
CD38
NCBI Official Synonym Symbols
T10
UniProt Protein Name
ADP-ribosyl cyclase 1
UniProt Synonym Protein Names
Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10
Protein Family
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
UniProt Gene Name
CD38
UniProt Synonym Gene Names
cADPr hydrolase 1
UniProt Entry Name
CD38_HUMAN
NCBI Protein Information
ADP-ribosyl cyclase 1; cADPr hydrolase 1; CD38 antigen (p45); NAD(+) nucleosidase; cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

UniProt Comments for CD38

CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lyase; Membrane protein, integral; Cell cycle regulation; Hydrolase; Apoptosis; EC 2.4.99.20; EC 3.2.2.6; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cell surface

Chromosomal Location of Human Ortholog: 4p15

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; nucleus

Molecular Function: transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity

Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; response to hydroperoxide; positive regulation of B cell proliferation; response to hypoxia; positive regulation of vasoconstriction; negative regulation of transcription, DNA-dependent; negative regulation of bone resorption; response to progesterone stimulus; negative regulation of apoptosis
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Research Articles on CD38

1. The frequency of CD38high antibody-secreting cells (ASCs) is increased during the acute phase of hepatitis A virus (HAV) infection. Substantial numbers of ASCs are non-HAV-specific and dominantly secrete IgM.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD38 antibody

 Reference Product  PubMed Publications
 CD4 antibody  >1038 publications with CD38 and CD4
 CD27 antibody  >206 publications with CD38 and CD27
 IL6 antibody  >24 publications with CD38 and IL6
 LCK antibody  >8 publications with CD38 and LCK
 BST1 antibody  >1 publications with CD38 and BST1

Pathways associated with anti-CD38 antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram

Diseases associated with anti-CD38 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1777 publications with CD38 and Neoplasms
 Cardiovascular Diseases Antibodies  >393 publications with CD38 and Cardiovascular Diseases
 Inflammation Antibodies  >204 publications with CD38 and Inflammation
 Necrosis Antibodies  >185 publications with CD38 and Necrosis
 Nervous System Diseases Antibodies  >88 publications with CD38 and Nervous System Diseases
 Anemia Antibodies  >86 publications with CD38 and Anemia
 Liver Diseases Antibodies  >84 publications with CD38 and Liver Diseases
 Neoplasms, Experimental Antibodies  >65 publications with CD38 and Neoplasms, Experimental
 Carcinoma Antibodies  >57 publications with CD38 and Carcinoma
 Disease Models, Animal Antibodies  >56 publications with CD38 and Disease Models, Animal

Organs/Tissues associated with anti-CD38 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3427 publications with CD38 and Blood
 Bone Marrow Antibodies  >1287 publications with CD38 and Bone Marrow
 Lymph Node Antibodies  >263 publications with CD38 and Lymph Node
 Liver Antibodies  >201 publications with CD38 and Liver
 Lymph Antibodies  >194 publications with CD38 and Lymph
 Spleen Antibodies  >149 publications with CD38 and Spleen
 Muscle Antibodies  >119 publications with CD38 and Muscle
 Tonsil Antibodies  >108 publications with CD38 and Tonsil
 Brain Antibodies  >105 publications with CD38 and Brain
 Pharynx Antibodies  >105 publications with CD38 and Pharynx
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