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CD146 Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS846000

Rabbit monoclonal antibody to detect CD146 in human samples.The CD146 antigen; also known as MCAM; is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2);… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CD146, Monoclonal Antibody
Full Product Name
Anti-CD146 Rabbit Monoclonal Antibody
Product Gene Name
anti-CD146 antibody
Product Synonym Gene Name
MCAM
Product Synonym Names
MCAM; MUC18; Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen
Clonality
Monoclonal
Isotype
IgG
Clone Number
RM249
Host
Rabbit
Species Reactivity
Human
Form/Format
Colorless liquid
In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purity/Purification
Affinity purified using protein A
Preparation and Storage
Store at -20 degree C for 12 months.
The antibody solution should be gently mixed before use.
Molecular Weight
57,605 Da
OMIM
M29277 mRNA
3D Structure
ModBase 3D Structure for P43121
Immunogen
A synthetic peptide corresponding to the residues near C-terminus of human CD146
Applications Tested/Suitable for anti-CD146 antibody
Immunohistochemistry (IHC); Western Blot (WB)
Application Notes for anti-CD146 antibody
IHC: 1:200-1:500 dilution
WB: 1:1000- 1:2000 dilution

Testing Data of anti-CD146 antibody

Rabbit Anti-CD146 Monoclonal Antibody – Cat# MBS846000

Other Notes

Small volumes of anti-CD146 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD146 purchase

MBS846000 is an antibody targeting CD146. Also known as Anti-CD146 Rabbit Monoclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD146. It may not necessarily be applicable to this product.

NCBI GI #
71274107
NCBI GeneID
4162
NCBI Accession #
NP_006491.2
UniProt Primary Accession #
P43121
UniProt Secondary Accession #
O95812; Q59E86; Q6PHR3; Q6ZTR2
UniProt Related Accession #
P43121
GenBank Nucleotide #
NM_006500.2
NCBI Official Full Name
cell surface glycoprotein MUC18
NCBI Official Synonym Full Names
melanoma cell adhesion molecule
NCBI Official Symbol
MCAM
NCBI Official Synonym Symbols
CD146; MUC18
UniProt Protein Name
Cell surface glycoprotein MUC18
UniProt Synonym Protein Names
Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD_antigen: CD146
Protein Family
Cell surface glycoprotein
UniProt Gene Name
MCAM
UniProt Synonym Gene Names
MUC18
NCBI Protein Information
cell surface glycoprotein MUC18

UniProt Comments for CD146

MCAM: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: external side of plasma membrane; focal adhesion

Biological Process: anatomical structure morphogenesis; angiogenesis; glomerular filtration
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Research Articles on CD146

1. Results provide evidence that MUC18 promotes viral infections both in vivo and in vitro.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD146 antibody

 Reference Product  PubMed Publications
 FGF2 antibody  >8 publications with CD146 and FGF2
 PTK2 antibody  >4 publications with CD146 and PTK2
 TGFB1 antibody  >4 publications with CD146 and TGFB1
 ATF3 antibody  >2 publications with CD146 and ATF3
 LGALS1 antibody  >2 publications with CD146 and LGALS1
 ESR1 antibody  >2 publications with CD146 and ESR1
 CYP1B1 antibody  >1 publications with CD146 and CYP1B1
 EDN1 antibody  >1 publications with CD146 and EDN1

Diseases associated with anti-CD146 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >41 publications with CD146 and Inflammation
 Lung Diseases Antibodies  >32 publications with CD146 and Lung Diseases
 Disease Models, Animal Antibodies  >29 publications with CD146 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >26 publications with CD146 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >26 publications with CD146 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >25 publications with CD146 and Adenocarcinoma
 Lung Neoplasms Antibodies  >24 publications with CD146 and Lung Neoplasms
 Breast Neoplasms Antibodies  >23 publications with CD146 and Breast Neoplasms
 Nervous System Diseases Antibodies  >20 publications with CD146 and Nervous System Diseases
 Prostatic Neoplasms Antibodies  >17 publications with CD146 and Prostatic Neoplasms

Organs/Tissues associated with anti-CD146 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >148 publications with CD146 and Blood
 Vascular Antibodies  >115 publications with CD146 and Vascular
 Skin Antibodies  >55 publications with CD146 and Skin
 Bone Antibodies  >55 publications with CD146 and Bone
 Lung Antibodies  >49 publications with CD146 and Lung
 Embryonic Tissue Antibodies  >41 publications with CD146 and Embryonic Tissue
 Bone Marrow Antibodies  >38 publications with CD146 and Bone Marrow
 Muscle Antibodies  >31 publications with CD146 and Muscle
 Brain Antibodies  >25 publications with CD146 and Brain
 Liver Antibodies  >23 publications with CD146 and Liver
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