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CFI-400945 ((1R)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS846427

CFI-400945 is a potent; ATP-competitive inhibitor of PLK4 (Polo-like kinase 4) (Ki = 0.2 nM). Displays anticancer properties. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells.  More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CFI-400945, Biochemical
Full Product Name
CFI-400945
Product Gene Name
CFI-400945 biochemical
Product Synonym Names
(1R; 2S)-2- (3- ( (E)-4- ( ( (2S; 6R)-2; 6-dimethylmorpholino) methyl) styryl)-1H-indazol-6-yl)-5'-methoxyspiro[cyclopropane-1; 3'-indolin]-2'-one
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C for 36 months.
Protect from air and light.
Molecular Weight
534.65
Salt Form
No
CAS Number
1338806-76-0
Cell-Permeable
Yes
Reconstitution
DMSO
SMILES
CC1CN(CC(O1)C)CC2=CC=C(C=C2)C=CC3=NNC4=C3C=CC(=C4)C5CC56C7=C(C=CC(=C7)OC)NC6=O
InChi
InChI=1S/C33H34N4O3/c1-20-17-37(18-21(2)40-20)19-23-6-4-22(5-7-23)8-12-29-26-11-9-24(14-31(26)36-35-29)28-16-33(28)27-15-25(39-3)10-13-30(27)34-32(33)38/h4-15,20-21,28H,16-19H2,1-3H3,(H,34,38)(H,35,36)/b12-8+/t20-,21+,28-,33-/m0/s1
InChi Key
DADASRPKWOGKCU-FVTQAUBDSA-N

Structure of CFI-400945 biochemical

CFI-400945 (1R Biochemical – Cat# MBS846427

Other Notes

Small volumes of CFI-400945 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CFI-400945 purchase

MBS846427 is a biochemical targeting CFI-400945.
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