LILRB2 Human Cellexp Recombinant Protein

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB2: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: cell surface; cytoplasm; extracellular space; integral to plasma membrane; membrane; plasma membrane

Molecular Function: cell adhesion molecule binding; inhibitory MHC class I receptor activity; MHC class I protein binding; protein binding; protein phosphatase 1 binding; receptor activity

Biological Process: cell surface receptor linked signal transduction; cell-cell signaling; cellular defense response; Fc receptor mediated inhibitory signaling pathway; heterotypic cell-cell adhesion; immune response; immune response-inhibiting cell surface receptor signaling pathway; negative regulation of antigen processing and presentation; negative regulation of calcium ion transport; negative regulation of immune response; negative regulation of T cell proliferation; neutrophil degranulation; positive regulation of regulatory T cell differentiation; positive regulation of T cell proliferation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction; regulation of immune response; signal transduction