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GOT1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847146

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate… More details

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Product Overview

Product Name
GOT1, Polyclonal Antibody
Full Product Name
Anti-GOT1 Antibody
Product Gene Name
anti-GOT1 antibody
Product Synonym Names
Aspartate aminotransferase cytoplasmic; cAspAT; Cysteine aminotransferase cytoplasmic; Cysteine transaminase cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Colorless liquid. In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH7.3; 30% glycerol and 0.01% sodium azide
Purity/Purification
Affinity purification. The antibody was purified by affinity chromatography
Specificity
Polyclonal antibody to detect endogenous levels of GOT1 in human and rat samples.
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use
Shelf life: ~12 months
Molecular Weight
44,147 Da
OMIM
138180
3D Structure
ModBase 3D Structure for P17174
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GOT1
Positive Control
WB: Jurkat, A549, PC12, H9C2 whole cell lysates.

Product Categories/Family for anti-GOT1 antibody

Signalling; Antibodies & Supporting Tools; Primary Antibodies (A-Z); Signal Transduction; Signal Transduction Antibodies (A-Z)
Applications Tested/Suitable for anti-GOT1 antibody
Western Blot (WB)
Application Notes for anti-GOT1 antibody
WB: 1:500-1:1000

Western Blot (WB) of anti-GOT1 antibody

Rabbit Anti-GOT1 Polyclonal Antibody – Cat# MBS847146

Other Notes

Small volumes of anti-GOT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GOT1 purchase

MBS847146 is an antibody targeting GOT1. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GOT1. It may not necessarily be applicable to this product.

NCBI GI #
4504067
NCBI GeneID
2805
NCBI Accession #
NP_002070.1
UniProt Primary Accession #
P17174
UniProt Secondary Accession #
Q5VW80; B2R6R7; B7Z7E9
UniProt Related Accession #
P17174
GenBank Nucleotide #
NM_002079.2
NCBI Official Full Name
aspartate aminotransferase, cytoplasmic
NCBI Official Synonym Full Names
glutamic-oxaloacetic transaminase 1, soluble
NCBI Official Symbol
GOT1
NCBI Official Synonym Symbols
cCAT; GIG18; cAspAT; ASTQTL1
UniProt Protein Name
Aspartate aminotransferase, cytoplasmic
UniProt Synonym Protein Names
Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; cCAT; Glutamate oxaloacetate transaminase 1; Transaminase A
Protein Family
Aspartate aminotransferase
UniProt Gene Name
GOT1
UniProt Synonym Gene Names
cAspAT; cCAT
UniProt Entry Name
AATC_HUMAN
NCBI Protein Information
aspartate aminotransferase, cytoplasmic; aspartate aminotransferase 1; aspartate transaminase 1; cysteine aminotransferase, cytoplasmic; cysteine transaminase, cytoplasmic; glutamate oxaloacetate transaminase 1; growth-inhibiting protein 18; transaminase

NCBI Summary for GOT1

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
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UniProt Comments for GOT1

GOT1: Plays a key role in amino acid metabolism. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Amino Acid Metabolism - cysteine and methionine; Transferase; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; EC 2.6.1.1; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.3

Chromosomal Location of Human Ortholog: 10q24.1-q25.1

Cellular Component: lysosome; cytoplasm; nerve terminal; nucleus; cytosol

Molecular Function: cysteine transaminase activity; phosphatidylserine decarboxylase activity; carboxylic acid binding; aspartate transaminase activity; pyridoxal phosphate binding

Biological Process: glutamate metabolic process; oxaloacetate metabolic process; glutamate catabolic process to aspartate; response to glucocorticoid stimulus; glucose metabolic process; aspartate biosynthetic process; pathogenesis; gluconeogenesis; 2-oxoglutarate metabolic process; methionine salvage; cellular response to insulin stimulus; sulfur amino acid metabolic process; glycerol biosynthetic process; fatty acid homeostasis; carbohydrate metabolic process; aspartate catabolic process; aspartate metabolic process; amino acid biosynthetic process; glutamate catabolic process to 2-oxoglutarate; polyamine metabolic process

Disease: Aspartate Aminotransferase, Serum Level Of, Quantitative Trait Locus 1
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Research Articles on GOT1

1. Alcohol consumption, smoking status, and metabolic syndrome impact on serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT), was determined.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GOT1 antibody

 Reference Product  PubMed Publications
 GOT2 antibody  >7 publications with GOT1 and GOT2
 MDH1 antibody  >5 publications with GOT1 and MDH1
 LDHB antibody  >3 publications with GOT1 and LDHB
 MDH2 antibody  >2 publications with GOT1 and MDH2

Pathways associated with anti-GOT1 antibody

 Products by Pathway  Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram

Diseases associated with anti-GOT1 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with GOT1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >4 publications with GOT1 and Nervous System Diseases
 Lung Neoplasms Antibodies  >4 publications with GOT1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >3 publications with GOT1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with GOT1 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >2 publications with GOT1 and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with GOT1 and Liver Diseases
 Fatty Liver Antibodies  >2 publications with GOT1 and Fatty Liver
 Fibrosis Antibodies  >2 publications with GOT1 and Fibrosis
 Weight Gain Antibodies  >1 publications with GOT1 and Weight Gain

Organs/Tissues associated with anti-GOT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with GOT1 and Blood
 Liver Antibodies  >7 publications with GOT1 and Liver
 Nerve Antibodies  >7 publications with GOT1 and Nerve
 Intestine Antibodies  >4 publications with GOT1 and Intestine
 Lung Antibodies  >4 publications with GOT1 and Lung
 Heart Antibodies  >4 publications with GOT1 and Heart
 Brain Antibodies  >4 publications with GOT1 and Brain
 Muscle Antibodies  >3 publications with GOT1 and Muscle
 Vascular Antibodies  >3 publications with GOT1 and Vascular
 Thyroid Antibodies  >2 publications with GOT1 and Thyroid
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