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CD6 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847409

CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular "scavenger receptor cysteine-rich" (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CD6, Monoclonal Antibody
Full Product Name
Anti-CD6 Antibody (Clone 3F7B5)
Product Gene Name
Product Synonym Names
T12; TP120; T-cell differentiation antigen CD6; CD6
Clonality
Monoclonal
Isotype
Mouse IgG1
Clone Number
3F7B5
Host
Mouse
Species Reactivity
Human
Form/Format
Colorless liquid. In 10mM PBS with 0.05% BSA & 0.05% azide
Purity/Purification
Protein A/G purification
Specificity
Monoclonal Antibody to detect CD6 in human samples
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use
Shelf life: ~12 months
Molecular Weight
71,801 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (60739113..60787849). Location: 11q13
OMIM
186720
3D Structure
ModBase 3D Structure for P30203
Immunogen
Human rheumatoid synovial T cell line ST-1
Positive Control
IHC: Human Tonsil
Applications Tested/Suitable for anti-CD6 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
Application Notes for anti-CD6 antibody
FC/FACS: 0.5-1ug/1x106 cells in 0.1 ml
IF: 0.5-1ug/ml
IHC: 0.5-1ug/ml for 30 minutes at room temperature

Immunohistochemistry (IHC) of anti-CD6 antibody

Mouse Anti-CD6 Monoclonal Antibody – Cat# MBS847409

Other Notes

Small volumes of anti-CD6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD6 purchase

MBS847409 is an antibody targeting CD6. Also known as Anti-CD6 Antibody (Clone 3F7B5). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
T-cell differentiation antigen CD6 isoform 2
NCBI Official Synonym Full Names
CD6 molecule
NCBI Official Symbol
CD6
NCBI Official Synonym Symbols
TP120
UniProt Protein Name
T-cell differentiation antigen CD6
UniProt Synonym Protein Names
T12; TP120
UniProt Gene Name
CD6
UniProt Entry Name
CD6_HUMAN
NCBI Protein Information
T-cell differentiation antigen CD6; T12; CD6 antigen

NCBI Summary for CD6

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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UniProt Comments for CD6

CD6: a type I membrane protein involved in cell adhesion. Binds to CD166. Expressed on thymocytes, peripheral T cells, a subset of B cells, and a subset of neurons. Mediates the binding of developing thymocytes with thymic epithelial cells. CD6- T cells are less autoreactive than CD6+ T cells. Phosphorylated on tyrosines and serines following T cell antigen receptor signaling. Five splice-variant isoforms have been described.

Protein type: Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; cell adhesion
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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