• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CRKL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847858

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase,… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
CRKL, Polyclonal Antibody
Full Product Name
Anti-CRKL Antibody
Product Gene Name
anti-CRKL antibody
Product Synonym Names
Crk-like protein
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Rat, Mouse, Human
Form/Format
Colorless liquid. In 0.42% Potassium phosphate; 0.87% NaCl; pH7.3; 30% glycerol; and 0.01% sodium azide
Purity/Purification
Affinity purification
Specificity
Affinity purified rabbit polyclonal antibody to detect CRKL expression in human, mouse and rat samples
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months
Molecular Weight
33,777 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (21271714..21308037). Location: 22q11.21
OMIM
602007
3D Structure
ModBase 3D Structure for P46109
Immunogen
KLH-conjugated synthetic peptide targeting a sequence within the center region of human CRKL.

Product Categories/Family for anti-CRKL antibody

Signal Transduction; Signal Transduction Antibodies (A-Z); Antibodies & Supporting Tools; Primary Antibodies (A-Z); Immunology; Immuno Oncology Antibodies; Antibodies for Epigenetics Research; Cancer Research; Epigenetic Regulation; Antibodies & Blocking
Applications Tested/Suitable for anti-CRKL antibody
Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-CRKL antibody
WB: 1:500-1:1000
WB data verified using HEK293T, SGC7901 whole cell lysates
IHC: 1:50-1:100
IF: 1:100-1:500

Immunocytochemistry/Immunofluorescence (ICC/IF)) of anti-CRKL antibody

Rabbit Anti-CRKL Polyclonal Antibody – Cat# MBS847858

Immunohistochemistry (IHC) of anti-CRKL antibody

Rabbit Anti-CRKL Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS847858

Western Blot (WB) of anti-CRKL antibody

Rabbit Anti-CRKL Polyclonal Antibody, Western Blot (WB) – Cat# MBS847858

Other Notes

Small volumes of anti-CRKL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRKL purchase

MBS847858 is an antibody targeting CRKL. Reactive in Rat, Mouse, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRKL. It may not necessarily be applicable to this product.

NCBI GI #
4885153
NCBI GeneID
1399
NCBI Accession #
NP_005198.1
UniProt Primary Accession #
P46109
UniProt Secondary Accession #
A8KA44; D3DX35
UniProt Related Accession #
P46109
GenBank Nucleotide #
NM_005207.3
NCBI Official Full Name
crk-like protein
NCBI Official Synonym Full Names
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
NCBI Official Symbol
CRKL
UniProt Protein Name
Crk-like protein
Protein Family
Crk-like protein
UniProt Gene Name
CRKL
UniProt Entry Name
CRKL_HUMAN
NCBI Protein Information
crk-like protein

UniProt Comments for CRKL

CRKL: an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cytosol; endosome

Molecular Function: protein binding; signal transducer activity; SH3/SH2 adaptor activity

Biological Process: anterior/posterior pattern formation; blood vessel development; organ morphogenesis; nerve growth factor receptor signaling pathway; activation of MAPKK activity; thymus development; heart development; Ras protein signal transduction; JNK cascade; parathyroid gland development
Show more

Research Articles on CRKL

1. study reveals a significant association between Crk protein expression with highly proliferative tumors and basal breast cancers of poor outcome; data highlight the physiological importance of Crk proteins in regulating growth of aggressive basal breast cancer cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRKL antibody

 Reference Product  PubMed Publications
 BCR antibody  >144 publications with CRKL and BCR
 CRK antibody  >132 publications with CRKL and CRK
 CBL antibody  >67 publications with CRKL and CBL
 GRB2 antibody  >48 publications with CRKL and GRB2
 CD34 antibody  >25 publications with CRKL and CD34
 LYN antibody  >17 publications with CRKL and LYN
 DAB1 antibody  >13 publications with CRKL and DAB1
 SYK antibody  >11 publications with CRKL and SYK
 BCAR1 antibody  >9 publications with CRKL and BCAR1
 PXN antibody  >9 publications with CRKL and PXN

Pathways associated with anti-CRKL antibody

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram

Diseases associated with anti-CRKL antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >142 publications with CRKL and Neoplasms
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >83 publications with CRKL and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Heart Defects, Congenital Antibodies  >12 publications with CRKL and Heart Defects, Congenital
 Disease Models, Animal Antibodies  >11 publications with CRKL and Disease Models, Animal
 Leukemia, Myeloid, Acute Antibodies  >11 publications with CRKL and Leukemia, Myeloid, Acute
 Craniofacial Abnormalities Antibodies  >10 publications with CRKL and Craniofacial Abnormalities
 DiGeorge Syndrome Antibodies  >10 publications with CRKL and DiGeorge Syndrome
 Neoplasms, Experimental Antibodies  >7 publications with CRKL and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >5 publications with CRKL and Breast Neoplasms
 Inflammation Antibodies  >4 publications with CRKL and Inflammation

Organs/Tissues associated with anti-CRKL antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >100 publications with CRKL and Blood
 Bone Antibodies  >20 publications with CRKL and Bone
 Nerve Antibodies  >19 publications with CRKL and Nerve
 Bone Marrow Antibodies  >18 publications with CRKL and Bone Marrow
 Brain Antibodies  >15 publications with CRKL and Brain
 Embryonic Tissue Antibodies  >12 publications with CRKL and Embryonic Tissue
 Lung Antibodies  >11 publications with CRKL and Lung
 Heart Antibodies  >7 publications with CRKL and Heart
 Stomach Antibodies  >5 publications with CRKL and Stomach
 Thymus Antibodies  >4 publications with CRKL and Thymus
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000