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CEP-37440

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848778

CEP-37440 is a potent and selective dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM (ALK cellular IC50 in 75% human plasma). The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits tumor… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CEP-37440, Biochemical
Full Product Name
CEP-37440
Product Synonym Names
2-[[5-chloro-2-[[ (6S)-6; 7; 8; 9-tetrahydro-6-[4- (2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-N-methyl-benzamide; CEP37440
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Molecular Weight
580.13
Solubility
>30 mg/ml in DMSO
Molecular Formula
C??H??ClN7O?
CAS Number
1391712-60-9
PubChem CID
71721648
SMILES
CNC (=O)C1=CC=CC=C1NC2=NC (=NC=C2Cl)NC3=C (C4=C (CC (CCC4)N5CCN (CC5)CCO)C=C3)OC
InChi
InChI=1S/C30H38ClN7O3/c1-32-29 (40)23-7-3-4-9-25 (23)34-28-24 (31)19-33-30 (36-28)35-26-11-10-20-18-21 (6-5-8-22 (20)27 (26)41-2)38-14-12-37 (13-15-38)16-17-39/h3-4,7,9-11,19,21,39H,5-6,8,12-18H2,1-2H3, (H,32,40)(H2,33,34,35,36)/t21-/m0/s1
InChi Key
BCSHRERPHLTPEE-NRFANRHFSA-N

Product Categories/Family for CEP-37440 biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors  (A-Z); ALK (Anaplastic Lymphoma Kinase) Inhibitors; Focal Adhesion Kinase (FAK)Inhibitors; Biochemicals; Biochemicals (A-Z); Enzyme Inhibitors (A-Z)

Structure of CEP-37440 biochemical

CEP-37440 Biochemical – Cat# MBS848778

Product References and Citations for CEP-37440 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/71721648

Other Notes

Small volumes of CEP-37440 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CEP-37440 purchase

MBS848778 is a biochemical targeting CEP-37440.
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