Sitravatinib (MGCD516)

Name: Sitravatinib (MGCD516); MyBioSource
Brand: MyBioSource
SKU: MBS848812
Price: 240 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848812

Sitravatinib (MGCD516; MG516) is a potent receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Sitravatinib, Biochemical

Full Product Name

Sitravatinib

Product Synonym Names

MGCD516; MGCD-516; N- (3-fluoro-4- ( (2- (5- ( ( (2-methoxyethyl) amino) methyl) pyridin-2-yl) thieno[3; 2-b]pyridin-7-yl) oxy) phenyl)-N- (4-fluorophenyl) cyclopropane-1; 1-dicarboxamide; MG516

Form/Format

Crystalline solid

Purity/Purification

>=98%

Preparation and Storage

Store at -20 degree C
Shelf life: ~36 months

Molecular Weight

629.68

Solubility

>30 mg/ml in DMSO

Molecular Formula

C??H??F?N?O?S

CAS Number

1123837-84-2

PubChem CID

25212148

SMILES

COCCNCC1=CN=C (C=C1)C2=CC3=NC=CC (=C3S2)OC4=C (C=C (C=C4)NC (=O)C5 (CC5)C (=O)NC6=CC=C (C=C6)F)F

InChi

InChI=1S/C33H29F2N5O4S/c1-43-15-14-36-18-20-2-8-25 (38-19-20)29-17-26-30 (45-29)28 (10-13-37-26)44-27-9-7-23 (16-24 (27)35)40-32 (42)33 (11-12-33)31 (41)39-22-5-3-21 (34)4-6-22/h2-10,13,16-17,19,36H,11-12,14-15,18H2,1H3, (H,39,41)(H,40,42)

InChi Key

WLAVZAAODLTUSW-UHFFFAOYSA-N

Product Categories/Family for Sitravatinib biochemical

Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z); Protein Tyrosine Kinase Inhibitors; Enzyme Inhibitors (A-Z)

Product References and Citations for Sitravatinib biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/25212148

Other Notes

Small volumes of Sitravatinib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Sitravatinib purchase

MBS848812 is a biochemical targeting Sitravatinib.