MRTX-1257 (MRTZ1257)

Name: MRTX-1257 (MRTZ1257); MyBioSource
Brand: MyBioSource
SKU: MBS848884
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS848884

MRTX-1257 is a potent, selective, and irreversible covalent inhibitor of KRAS G12C. MRTX-1257 inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 0.9 nM. Displays high selectivity for the Cys12 of KRAS G12C in NCI-H358 cells over other… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MRTX-1257, Biochemical

Full Product Name

MRTX-1257

Product Synonym Names

MRTZ1257; 2- ( (S)-1-acryloyl-4- (7- (8-methylnaphthalen-1-yl)-2- ( ( (S)-1-methylpyrrolidin-2-yl) methoxy)-5; 6; 7; 8-tetrahydropyrido[3; 4-d]pyrimidin-4-yl) piperazin-2-yl) acetonitrile; MRTX1257

Form/Format

White to off-white solid

Purity/Purification

>=98% by HPLC

Preparation and Storage

Store at -20 degree C
Shelf life: ~36 months

Molecular Weight

565.72

Solubility

>40 mg/ml in DMSO

Molecular Formula

C??H??N?O?

CAS Number

2206736-04-9

PubChem CID

134326100

SMILES

CC1=C2C (=CC=C1)C=CC=C2N3CCC4=C (C3)N=C (N=C4N5CCN (C (C5)CC#N)C (=O)C=C)OCC6CCCN6C

InChi

InChI=1S/C33H39N7O2/c1-4-30 (41)40-19-18-39 (20-25 (40)13-15-34)32-27-14-17-38 (29-12-6-10-24-9-5-8-23 (2)31 (24)29)21-28 (27)35-33 (36-32)42-22-26-11-7-16-37 (26)3/h4-6,8-10,12,25-26H,1,7,11,13-14,16-22H2,2-3H3

InChi Key

YRYQLVCTQFBRLD-UHFFFAOYSA-N

Product Categories/Family for MRTX-1257 biochemical

Enzyme Inhibitors; Enzyme Inhibitors (A-Z); Biochemicals; Biochemicals (A-Z); GTPase Inhibitors

Product References and Citations for MRTX-1257 biochemical

https://pubchem.ncbi.nlm.nih.gov/compound/134326100

Other Notes

Small volumes of MRTX-1257 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MRTX-1257 purchase

MBS848884 is a biochemical targeting MRTX-1257.