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LILRB4/Cd85k/ILT3 (LILRB4) Human Cellexp Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS849815

Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
LILRB4/CD85k/ILT3, Active Protein
Full Product Name
Human CellExp LILRB4/CD85k/ILT3, Mouse Recombinant
Product Gene Name
LILRB4 active protein
Product Synonym Names
LILRB4; ILT3; LIR5; CD85K; HM18
Host
HEK293 cells
Form/Format
Lyophilized from 0.22 um filtered solution in PBS pH7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.
Purity/Purification
>95% by SDS-PAGE
Preparation and Storage
Store at -20 degree C
Centrifuge the vial prior to opening.
Shelf life: ~12 months
Molecular Weight
33,049 Da
3D Structure
ModBase 3D Structure for Q64281
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Gene Source
Mouse
Endotoxin
<1.0 EU per/ug
Biological Activity
Immobilized Human ANGPTL7, His Tag at 5 ug/mL (100 uL/well) can bind Mouse LILRB4, Fc Tag with a linear range of 0.156-1.25 ug/mL.
Measured by its binding ability in a functional ELISA.
Reconstitution Instruction
Reconstitute in sterile deionized water to the desired protein concentration.

Product Categories/Family for LILRB4 active protein

Cytokines; Growth Factors & Hormones; Human cell expressed recombinant proteins; Proteins; Enzymes; Human cell expressed recombinant proteins Cytokines; BAFFs; Cytokines & Growth Factors (A-Z); Proteins & Enzymes (A-Z); Signaling Pathways; TNF Signaling P

SDS-Page of LILRB4 active protein

Human Cellexp LILRB4 Active Protein – Cat# MBS849815

Testing Data of LILRB4 active protein

Human Cellexp LILRB4 Active Protein, Testing Data – Cat# MBS849815

Testing Data of LILRB4 active protein

Human Cellexp LILRB4 Active Protein, Testing Data – Cat# MBS849815

Other Notes

Small volumes of LILRB4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LILRB4 purchase

MBS849815 is an active protein targeting LILRB4. Also known as Human CellExp LILRB4/CD85k/ILT3, Mouse Recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for LILRB4. It may not necessarily be applicable to this product.

NCBI GI #
7305097
NCBI GeneID
14728
NCBI Accession #
NP_038560.1
UniProt Primary Accession #
Q64281
UniProt Secondary Accession #
Q64312
UniProt Related Accession #
Q64281
GenBank Nucleotide #
NM_013532.3
NCBI Official Full Name
leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 1
NCBI Official Synonym Full Names
leukocyte immunoglobulin-like receptor, subfamily B, member 4A
NCBI Official Symbol
Lilrb4a
NCBI Official Synonym Symbols
HM18; ILT3; gp49; CD85K; Gp49b; LIR-5; Lilrb4
UniProt Protein Name
Leukocyte immunoglobulin-like receptor subfamily B member 4
UniProt Synonym Protein Names
Mast cell surface glycoprotein Gp49B; CD_antigen: CD85k
Protein Family
Leukocyte immunoglobulin-like receptor subfamily
UniProt Gene Name
Lilrb4
UniProt Synonym Gene Names
Gp49b
UniProt Entry Name
LIRB4_MOUSE
NCBI Protein Information
leukocyte immunoglobulin-like receptor subfamily B member 4

UniProt Comments for LILRB4

LILRB4: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: integral to membrane; membrane; plasma membrane

Biological Process: adaptive immune response; immune system process
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Research Articles on LILRB4

1. Results suggest that plasma cell development from memory and marginal zone B cells, as well as subsequent antibody production, are suppressed via glycoprotein 49B (gp49B).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with LILRB4 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >13 publications with LILRB4 and Inflammation
 Hypersensitivity Antibodies  >9 publications with LILRB4 and Hypersensitivity
 Neoplasms Antibodies  >8 publications with LILRB4 and Neoplasms
 Bone Marrow Diseases Antibodies  >5 publications with LILRB4 and Bone Marrow Diseases
 Necrosis Antibodies  >4 publications with LILRB4 and Necrosis
 Hematologic Diseases Antibodies  >2 publications with LILRB4 and Hematologic Diseases
 Carcinoma Antibodies  >2 publications with LILRB4 and Carcinoma
 Lung Diseases Antibodies  >2 publications with LILRB4 and Lung Diseases
 Cardiovascular Diseases Antibodies  >1 publications with LILRB4 and Cardiovascular Diseases
 Skin Diseases Antibodies  >1 publications with LILRB4 and Skin Diseases

Organs/Tissues associated with LILRB4 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >75 publications with LILRB4 and Blood
 Bone Antibodies  >17 publications with LILRB4 and Bone
 Bone Marrow Antibodies  >17 publications with LILRB4 and Bone Marrow
 Spleen Antibodies  >3 publications with LILRB4 and Spleen
 Joint Antibodies  >2 publications with LILRB4 and Joint
 Pancreas Antibodies  >2 publications with LILRB4 and Pancreas
 Embryonic Tissue Antibodies  >1 publications with LILRB4 and Embryonic Tissue
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