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Caveolin-1 (CAV1) Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS850436

MBS850436 is an antibody targeting CAV1. Also known as Caveolin-1 Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Caveolin-1 (CAV1), Antibody
Full Product Name
Caveolin-1 Antibody
Product Gene Name
anti-CAV1 antibody
Clone Number
19-D6
Species Reactivity
Human, Mouse, Rat
Form/Format
In 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.
Specificity
This antibody is produced by immunizing mouse with a synthetic peptide (KLH-coupled) corresponding to near C-terminal residues of caveolin-1.
Preparation and Storage
Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.
Molecular Weight
21kDa
3D Structure
ModBase 3D Structure for P49817
Preservative
0.05% Sodium Azide.
Cellular Localization
Cell Membrane or Golgi membrane
Positive Control
A431, NIH/3T3
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CAV1 antibody
Western Blot (WB)
Application Notes for anti-CAV1 antibody
WB: 1:500-1,000

Testing Data #3 of anti-CAV1 antibody

Anti-CAV1 Antibody – Cat# MBS850436

Testing Data #4 of anti-CAV1 antibody

Anti-CAV1 Antibody, Testing Data #4 – Cat# MBS850436

Product References and Citations for anti-CAV1 antibody

1. Scherer P.E., Tang Z., et al. J. Biol. Chem. 270:16395-16401(1995). 2. Okamoto, T., et al. Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J. Biol. Chem. 273: 5419-5422 (1998). 3. Smart, E.J., et al. Caveolins, liquid-ordered domains, and signal transduction. Mol. Cell. Biol. 19: 7289-7304(1999).

Other Notes

Small volumes of anti-CAV1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CAV1. It may not necessarily be applicable to this product.

NCBI GI #
340139110
NCBI GeneID
12389
NCBI Accession #
NP_001229993.1
UniProt Primary Accession #
P49817
UniProt Secondary Accession #
Q8C1X7; Q8CBP4; Q9QYH3; Q9QYH4
UniProt Related Accession #
P49817
GenBank Nucleotide #
NM_001243064.1
NCBI Official Full Name
caveolin-1 isoform 2
NCBI Official Synonym Full Names
caveolin 1, caveolae protein
NCBI Official Symbol
Cav1
NCBI Official Synonym Symbols
Cav; Cav-1
UniProt Protein Name
Caveolin-1
Protein Family
Caveolin
UniProt Gene Name
Cav1
UniProt Synonym Gene Names
Cav
NCBI Protein Information
caveolin-1

UniProt Comments for CAV1

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation (). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (PubMed:10816572). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19546242).
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Research Articles on CAV1

1. These results suggest that the phosphorylated CAV1 functions to activate autophagy through binding to the BECN1/VPS34 complex under oxidative stress and to protect against ischemic damage.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CAV1 antibody

 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram

Diseases associated with anti-CAV1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >346 publications with CAV1 and Neoplasms
 Cardiovascular Diseases Antibodies  >124 publications with CAV1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >75 publications with CAV1 and Heart Diseases
 Breast Neoplasms Antibodies  >74 publications with CAV1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >59 publications with CAV1 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >51 publications with CAV1 and Neoplasm Metastasis
 Prostatic Neoplasms Antibodies  >48 publications with CAV1 and Prostatic Neoplasms
 Inflammation Antibodies  >47 publications with CAV1 and Inflammation
 Hypertension Antibodies  >42 publications with CAV1 and Hypertension
 Fibrosis Antibodies  >40 publications with CAV1 and Fibrosis

Organs/Tissues associated with anti-CAV1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >377 publications with CAV1 and Muscle
 Heart Antibodies  >227 publications with CAV1 and Heart
 Brain Antibodies  >196 publications with CAV1 and Brain
 Lung Antibodies  >134 publications with CAV1 and Lung
 Kidney Antibodies  >108 publications with CAV1 and Kidney
 Artery Antibodies  >101 publications with CAV1 and Artery
 Prostate Antibodies  >68 publications with CAV1 and Prostate
 Embryonic Tissue Antibodies  >61 publications with CAV1 and Embryonic Tissue
 Liver Antibodies  >60 publications with CAV1 and Liver
 Intestine Antibodies  >42 publications with CAV1 and Intestine
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