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NAC1 Antibody – Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS850563

NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NAC1, Antibody
Full Product Name
NAC1 Antibody
Product Gene Name
anti-NAC1 antibody
Product Synonym Names
NAC1; BEND8; NAC-1; BTBD14B; FLJ37383; NACC1
Isotype
IgG1
Clone Number
6H2
Host
Mouse
Species Reactivity
Human
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Preparation and Storage
Store at 4 degree C, for long term storage, store at-20 degree C.
Molecular Weight
58kDa
OMIM
610672
3D Structure
ModBase 3D Structure for Q96RE7
Immunogen
Purified recombinant fragment of human NACC1 expressed in E. Coli.

Product Categories/Family for anti-NAC1 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-NAC1 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-NAC1 antibody
WB: 1:500-1:2000
IHC: 1:200-1:1000
ELISA: 1:10000

Western Blot (WB) of anti-NAC1 antibody

Figure 1: Western blot analysis using NACC1 mAb against HEK293 (1) and NACC1-hIgGFc transfected HEK293 (2) cell lysate.
Mouse Anti-NAC1 Antibody – Cat# MBS850563

Immunohistochemistry (IHC) of anti-NAC1 antibody

Figure 2: Immunohistochemical analysis of paraffin-embedded mammary cancer tissues (left) and ovarian cancer tissues (right) using NACC1 mouse mAb with DAB staining.
Mouse Anti-NAC1 Antibody, Immunohistochemistry (IHC) – Cat# MBS850563

Other Notes

Small volumes of anti-NAC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NAC1 purchase

MBS850563 is an antibody targeting NAC1. Also known as NAC1 Antibody. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for NAC1. It may not necessarily be applicable to this product.

NCBI GI #
16418383
NCBI GeneID
112939
NCBI Accession #
NP_443108.1
UniProt Primary Accession #
Q96RE7
UniProt Related Accession #
Q96RE7
GenBank Nucleotide #
NM_052876.3
NCBI Official Full Name
nucleus accumbens-associated protein 1
NCBI Official Synonym Full Names
nucleus accumbens associated 1
NCBI Official Symbol
NACC1
NCBI Official Synonym Symbols
NAC1; BEND8; NAC-1; NECFM; BTBD30; BTBD14B
UniProt Protein Name
Nucleus accumbens-associated protein 1
UniProt Synonym Protein Names
BTB/POZ domain-containing protein 14B
UniProt Gene Name
NACC1
UniProt Synonym Gene Names
BTBD14B; NAC1; NAC-1
NCBI Protein Information
nucleus accumbens-associated protein 1

NCBI Summary for NAC1

This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012]
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UniProt Comments for NAC1

Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
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Research Articles on NAC1

1. knockdown of HOXA9 abrogated NAC1induced drug resistance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NAC1 antibody

 Reference Product  PubMed Publications
 GADD45GIP1 antibody  >3 publications with NAC1 and GADD45GIP1
 HDAC4 antibody  >2 publications with NAC1 and HDAC4
 NANOG antibody  >1 publications with NAC1 and NANOG
 PSMD7 antibody  >1 publications with NAC1 and PSMD7
 CUL3 antibody  >1 publications with NAC1 and CUL3

Diseases associated with anti-NAC1 antibody

 Disease Name  Pubmed Publications
 Substance-Related Disorders Antibodies  >3 publications with NAC1 and Substance-Related Disorders
 Neoplasms, Experimental Antibodies  >2 publications with NAC1 and Neoplasms, Experimental
 Poisoning Antibodies  >1 publications with NAC1 and Poisoning
 Hyperplasia Antibodies  >1 publications with NAC1 and Hyperplasia
 Breast Neoplasms Antibodies  >1 publications with NAC1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >1 publications with NAC1 and Nervous System Diseases

Organs/Tissues associated with anti-NAC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >22 publications with NAC1 and Nerve
 Brain Antibodies  >16 publications with NAC1 and Brain
 Embryonic Tissue Antibodies  >4 publications with NAC1 and Embryonic Tissue
 Uterus Antibodies  >2 publications with NAC1 and Uterus
 Lymph Node Antibodies  >2 publications with NAC1 and Lymph Node
 Connective Tissue Antibodies  >1 publications with NAC1 and Connective Tissue
 Blood Antibodies  >1 publications with NAC1 and Blood
 Thyroid Antibodies  >1 publications with NAC1 and Thyroid
 Thymus Antibodies  >1 publications with NAC1 and Thymus
 Bone Antibodies  >1 publications with NAC1 and Bone
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