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NEIL3 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS851221

MBS851221 is an antibody targeting NEIL3. Also known as NEIL3 Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NEIL3, Antibody
Full Product Name
NEIL3 Antibody
Product Gene Name
Product Synonym Names
Endonuclease VIII-like 3; Nei-like 3; DNA glycosylase FPG2
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
NEIL3 antibody detects endogenous levels of total NEIL3 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
67,769 Da
OMIM
608934
3D Structure
ModBase 3D Structure for Q8TAT5
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human NEIL3.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-NEIL3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-NEIL3 antibody
WB: 1:500~1:1000
ELISA: 1:40000

Western Blot (WB) of anti-NEIL3 antibody

Western blot analysis of extracts from COLO cells, HUVEC cells, HepG2 cells and HeLa cells, using NEIL3 antibody. For Research Use Only
Anti-NEIL3 Antibody – Cat# MBS851221

Product References and Citations for anti-NEIL3 antibody

Takao M., J. Biol. Chem. 277:42205-42213(2002). Ota T., Nat. Genet. 36:40-45(2004). The MGC Project Team, Genome Res. 14:2121-2127(2004).

Other Notes

Small volumes of anti-NEIL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NEIL3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
endonuclease 8-like 3
NCBI Official Synonym Full Names
nei like DNA glycosylase 3
NCBI Official Symbol
NEIL3
NCBI Official Synonym Symbols
FGP2; FPG2; NEI3; ZGRF3; hFPG2; hNEI3
UniProt Protein Name
Endonuclease 8-like 3
UniProt Synonym Protein Names
DNA glycosylase FPG2; DNA glycosylase/AP lyase Neil3; Endonuclease VIII-like 3; Nei-like protein 3
Protein Family
UniProt Gene Name
NEIL3
NCBI Protein Information
endonuclease 8-like 3

NCBI Summary for NEIL3

NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]
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UniProt Comments for NEIL3

DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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