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GluR5 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS851676

MBS851676 is an antibody targeting GluR5. Also known as GluR5 Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GluR5, Antibody
Full Product Name
GluR5 Antibody
Product Gene Name
anti-GluR5 antibody
Product Synonym Names
EAA3; EEA3; GLR5; GLUTAMATE RECEPTOR 5; excitatory amino acid receptor 3; glutamate receptor; ionotropic; kainate 1 isoform 1 precursor; glutamate receptor; ionotropic; kainate 1 isoform 2 precursor
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
GluR5 antibody detects endogenous levels of total GluR5 protein.
Preparation and Storage
Store at-20 degree C for 1 year
Molecular Weight
102,631 Da
OMIM
138245
3D Structure
ModBase 3D Structure for P39086
Immunogen
The antiserum was produced against synthesized peptide derived from human GluR5.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GluR5 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-GluR5 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:5000

Immunohistochemistry (IHC) of anti-GluR5 antibody

Peptide-+ Immunohistochemical analysis of paraffin-embedded human brain tissue using GluR5 antibody.
Anti-GluR5 Antibody – Cat# MBS851676

Western Blot (WB) of anti-GluR5 antibody

Western blot analysis of extracts from mouse brain, using GluR5 antibody.
Anti-GluR5 Antibody, Western Blot (WB) – Cat# MBS851676

Product References and Citations for anti-GluR5 antibody

Ana V. Paternain, J. Neurosci., Jan 2000; 20: 196. Zhao Ren, J. Biol. Chem., Dec 2003; 278: 52700-52709. MICHAEL A. ROGAWSKI, Ann. N.Y. Acad. Sci., Apr 2003; 985: 150. Yoshinori Sahara, J. Neurosci., Sep 1997; 17: 6611.

Other Notes

Small volumes of anti-GluR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GluR5. It may not necessarily be applicable to this product.

NCBI GI #
4504117
NCBI GeneID
2897
NCBI Accession #
NP_000821.1
UniProt Primary Accession #
P39086
UniProt Secondary Accession #
Q13001; Q86SU9
UniProt Related Accession #
P39086
GenBank Nucleotide #
NM_000830.4
NCBI Official Full Name
glutamate receptor ionotropic, kainate 1 isoform 1
NCBI Official Synonym Full Names
glutamate ionotropic receptor kainate type subunit 1
NCBI Official Symbol
GRIK1
NCBI Official Synonym Symbols
EAA3; EEA3; GLR5; GLUR5; GluK1; gluR-5
UniProt Protein Name
Glutamate receptor ionotropic, kainate 1
UniProt Synonym Protein Names
Excitatory amino acid receptor 3; EAA3; Glutamate receptor 5; GluR-5; GluR5
Protein Family
Glutamate receptor ionotropic
UniProt Gene Name
GRIK1
UniProt Synonym Gene Names
GLUR5; GluK1; EAA3; GluR-5; GluR5
NCBI Protein Information
glutamate receptor ionotropic, kainate 1

NCBI Summary for GluR5

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for GluR5

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
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Research Articles on GluR5

1. DRD2 A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A are not associated with alcoholism alone or in interaction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GluR5 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Ca-permeable Kainate Receptor Pathway antibodies  Activation Of Ca-permeable Kainate Receptor Pathway Diagram
 Activation Of Kainate Receptors Upon Glutamate Binding Pathway antibodies  Activation Of Kainate Receptors Upon Glutamate Binding Pathway Diagram
 Activation Of Na-permeable Kainate Receptors Pathway antibodies  Activation Of Na-permeable Kainate Receptors Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Ionotropic Activity Of Kainate Receptors Pathway antibodies  Ionotropic Activity Of Kainate Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram

Diseases associated with anti-GluR5 antibody

 Disease Name  Pubmed Publications
 Epilepsy Antibodies  >5 publications with GluR5 and Epilepsy
 Nervous System Diseases Antibodies  >5 publications with GluR5 and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with GluR5 and Brain Diseases
 Pain Antibodies  >2 publications with GluR5 and Pain
 Seizures Antibodies  >2 publications with GluR5 and Seizures
 Liver Diseases Antibodies  >1 publications with GluR5 and Liver Diseases
 Cognition Disorders Antibodies  >1 publications with GluR5 and Cognition Disorders
 Inflammation Antibodies  >1 publications with GluR5 and Inflammation
 Learning Disorders Antibodies  >1 publications with GluR5 and Learning Disorders

Organs/Tissues associated with anti-GluR5 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with GluR5 and Brain
 Embryonic Tissue Antibodies  >1 publications with GluR5 and Embryonic Tissue
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