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Thyroid Hormone Receptor Beta (THB1) Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS851867

MBS851867 is an antibody targeting THB1. Also known as Thyroid Hormone Receptor beta Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Thyroid Hormone Receptor beta (THB1), Antibody
Full Product Name
Thyroid Hormone Receptor beta Antibody
Product Gene Name
Product Synonym Names
C-ERBA-BETA; ERBA2; NR1A2; THR1
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
Thyroid Hormone Receptor beta antibody detects endogenous levels of total Thyroid Hormone Receptor beta protein.
Preparation and Storage
Store at-20 degree C for 1 year
Molecular Weight
54,449 Da
OMIM
145650
3D Structure
ModBase 3D Structure for P10828
Immunogen
The antiserum was produced against synthesized peptide derived from human Thyroid Hormone Receptor beta antibody.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-THB1 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-THB1 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:5000

Immunohistochemistry (IHC) of anti-THB1 antibody

Peptide-+ Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Thyroid Hormone Receptor beta antibody.
Anti-THB1 Antibody – Cat# MBS851867

Western Blot (WB) of anti-THB1 antibody

Western blot analysis of extracts from LOVO cells, using Thyroid Hormone Receptor beta antibody.
Anti-THB1 Antibody, Western Blot (WB) – Cat# MBS851867

Product References and Citations for anti-THB1 antibody

Sharon Y. Wu, J. Clin. Endocrinol. Metab., May 2006; 91: 1887-1895. J. D. Safer, J. Clin. Endocrinol. Metab., Sep 1999; 84: 3099-3109. Joaquin Lado-Abeal, J. Clin. Endocrinol. Metab., Mar 2005; 90: 1760-1767. Sunee Mamanasiri, J. Clin. Endocrinol. Metab., Sep 2006; 91: 3471-3477.

Other Notes

Small volumes of anti-THB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for THB1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
thyroid hormone receptor beta isoform a
NCBI Official Synonym Full Names
thyroid hormone receptor beta
NCBI Official Symbol
THRB
NCBI Official Synonym Symbols
GRTH; PRTH; THR1; ERBA2; NR1A2; THRB1; THRB2; C-ERBA-2; C-ERBA-BETA
UniProt Protein Name
Thyroid hormone receptor beta
UniProt Synonym Protein Names
Nuclear receptor subfamily 1 group A member 2; c-erbA-2; c-erbA-beta
UniProt Gene Name
THRB
UniProt Synonym Gene Names
ERBA2; NR1A2; THR1
NCBI Protein Information
thyroid hormone receptor beta

NCBI Summary for THB1

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for THB1

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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