ADH5: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
Protein type: Lipid Metabolism - fatty acid; Oxidoreductase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Xenobiotic Metabolism - metabolism by cytochrome P450; Amino Acid Metabolism - tyrosine; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - retinol; EC 1.1.1.1; Mitochondrial; EC 1.1.1.284; Energy Metabolism - methane
Cellular Component: mitochondrion; cytoplasm; nucleus
Molecular Function: mevaldate reductase activity; protein homodimerization activity; zinc ion binding; (R)-2-hydroxyglutarate dehydrogenase activity; phenylcoumaran benzylic ether reductase activity; aldo-keto reductase activity; metal ion binding; formaldehyde dehydrogenase activity; alcohol dehydrogenase activity; oxidoreductase activity; arabinose reductase activity; isocitrate dehydrogenase activity; C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity; epoxide dehydrogenase activity; (R)-2-hydroxyisocaproate dehydrogenase activity; steroid dehydrogenase activity; 3-ketoglucose-reductase activity; steroid dehydrogenase activity, acting on the CH-CH group of donors; D-arabinitol dehydrogenase (NADP+) activity; 2-hydroxytetrahydrofuran dehydrogenase activity; S-(hydroxymethyl)glutathione dehydrogenase activity; 5-exo-hydroxycamphor dehydrogenase activity; acetoin dehydrogenase activity; fatty acid binding; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; xylose reductase activity; gluconate dehydrogenase activity
Biological Process: respiratory system process; response to nitrosative stress; ethanol catabolic process; formaldehyde catabolic process; peptidyl-cysteine S-nitrosylation; response to redox state; response to lipopolysaccharide; ethanol oxidation; retinoid metabolic process; positive regulation of blood pressure
Show more