Rabbit Anti-PROC Polyclonal Antibody – Cat# MBS856977

Western blot analysis on human plasma using anti-vitamin K-dependent protein C polyclonal antibody.

Vitamin K-Dependent Protein C (PROC) Antibody – Rabbit Polyclonal

Name: PROC Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS856977
Price: 385 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS856977

Protein C is a Vitamin K-dependent glycoprotein that is produced in the liver. Protein C is similar to the prothombin group of blood coagulation factors in its primary structure. Normal protein C concentration in human plasma is approximately 1-3 ng/ml and… More details

$385 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Vitamin K-dependent protein C (PROC), Polyclonal Antibody

Full Product Name

Vitamin K-dependent protein C Antibody

Product Gene Name

anti-PROC antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid; 1*TBS (pH 7.4), 0.5% BSA, 25% Glycerol, 0.05% Sodium Azide

Purity/Purification

Immunogen Affinity Purified

Concentration

1mg/ml (lot specific)

Specificity

This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to human Vitamin K-dependent protein C.

Preparation and Storage

Store at +4°C after thawing. Aliquot, store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.

Molecular Weight

52/80kDa

OMIM

176860

3D Structure

ModBase 3D Structure for P04070

Positive Control

K562, human plasma

Cellular Localization

Secretory protein

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-PROC antibody

Western Blot (WB)

Application Notes for anti-PROC antibody

Recommended Dilutions: WB: 1:1,000

Other Notes

Small volumes of anti-PROC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PROC purchase

MBS856977 is an antibody targeting PROC. Also known as Vitamin K-dependent protein C Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PROC. It may not necessarily be applicable to this product.

NCBI GI #

4506115

NCBI GeneID

5624

NCBI Accession #

NP_000303.1

UniProt Primary Accession #

P04070

UniProt Secondary Accession #

Q15189; Q15190; Q16001; Q53S74; Q9UC55; B4DPQ7

UniProt Related Accession #

P04070

GenBank Nucleotide #

NM_000312.3

NCBI Official Full Name

vitamin K-dependent protein C preproprotein

NCBI Official Synonym Full Names

protein C, inactivator of coagulation factors Va and VIIIa

NCBI Official Symbol

PROC

NCBI Official Synonym Symbols

PC; APC; PROC1; THPH3; THPH4

UniProt Protein Name

Vitamin K-dependent protein C

UniProt Synonym Protein Names

Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV

Protein Family

Vitamin K-dependent protein

UniProt Gene Name

PROC

NCBI Protein Information

vitamin K-dependent protein C

NCBI Summary for PROC

This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]

UniProt Comments for PROC

Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).

Research Articles on PROC

1. We recently identified a venous thrombosis patient whose plasma level of protein C antigen is normal, but its anticoagulant activity is only 34 % of the normal level. Genetic analysis revealed that the proband and her younger brother carry a novel heterozygous mutation c.346G>A, p.Gly74Ser (G74S) in PROC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PROC antibody

Reference Product	PubMed Publications
GGCX antibody	>6 publications with PROC and GGCX
PROS1 antibody	>4 publications with PROC and PROS1
THBD antibody	>2 publications with PROC and THBD
PROCR antibody	>2 publications with PROC and PROCR
SERPINA5 antibody	>1 publications with PROC and SERPINA5

Pathways associated with anti-PROC antibody

Products by Pathway	Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Common Pathway antibodies	Common Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies	Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Gamma-carboxylation Of Protein Precursors Pathway antibodies	Gamma-carboxylation Of Protein Precursors Pathway Diagram
Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies	Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram

Diseases associated with anti-PROC antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>716 publications with PROC and Neoplasms
Cardiovascular Diseases Antibodies	>129 publications with PROC and Cardiovascular Diseases
Cell Transformation, Neoplastic Antibodies	>119 publications with PROC and Cell Transformation, Neoplastic
Drug Toxicity Antibodies	>118 publications with PROC and Drug Toxicity
Liver Diseases Antibodies	>90 publications with PROC and Liver Diseases
Thrombosis Antibodies	>76 publications with PROC and Thrombosis
Kidney Diseases Antibodies	>65 publications with PROC and Kidney Diseases
Liver Neoplasms Antibodies	>65 publications with PROC and Liver Neoplasms
Protein C Deficiency Antibodies	>59 publications with PROC and Protein C Deficiency
Blood Coagulation Disorders Antibodies	>59 publications with PROC and Blood Coagulation Disorders

Organs/Tissues associated with anti-PROC antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>699 publications with PROC and Brain
Liver Antibodies	>597 publications with PROC and Liver
Kidney Antibodies	>382 publications with PROC and Kidney
Lung Antibodies	>200 publications with PROC and Lung
Spleen Antibodies	>87 publications with PROC and Spleen
Connective Tissue Antibodies	>87 publications with PROC and Connective Tissue
Testis Antibodies	>61 publications with PROC and Testis
Uterus Antibodies	>22 publications with PROC and Uterus
Mammary Gland Antibodies	>15 publications with PROC and Mammary Gland