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PLCZ1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS858237

Rabbit polyclonal PLCZ1 (1) antibody was raised against a recombinate human PLCZ1 protein 322-572aa (BC125067). More details

$430 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PLCZ1, Polyclonal Antibody
Full Product Name
PLCZ1 Antibody
Product Gene Name
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Reacts with: Human
Predicted: Rat, Mouse
Form/Format
Lyohphilized PLCZ1 antibody purified by protein affinity column containing 1% BSA and 0.02% NaN3
Preparation and Storage
Already reconstituted in 200 ul sterile H2O. The antibody is stable for atleast one year when stored at -20°C after reconstitution. Avoid repeated freeze/defrost cycles.
Molecular Weight
57,804 Da
OMIM
608075
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PLCZ1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PLCZ1 antibody
ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:500-1:1,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.

Western Blot (WB) of anti-PLCZ1 antibody

Rabbit Anti-PLCZ1 Polyclonal Antibody – Cat# MBS858237

Immunohistochemistry (IHC) of anti-PLCZ1 antibody

Rabbit Anti-PLCZ1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS858237

Product References and Citations for anti-PLCZ1 antibody

(1) Nomikos, M., Elgmati, K., Theodoridou, M. et al. Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP(2) hydrolysis activity of sperm PLCzeta. Biochem. J. 434 (2), 211-217 (2011).

Other Notes

Small volumes of anti-PLCZ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLCZ1 purchase

MBS858237 is an antibody targeting PLCZ1. Also known as PLCZ1 Antibody. Reactive in Reacts with: Human
Predicted: Rat, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PLCZ1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homo sapiens phospholipase C, zeta 1, mRNA
NCBI Official Synonym Full Names
phospholipase C zeta 1
NCBI Official Symbol
PLCZ1
NCBI Official Synonym Symbols
SPGF17; PLCzeta; NYD-SP27; PLC-zeta-1
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
UniProt Synonym Protein Names
Phosphoinositide phospholipase C-zeta-1; Phospholipase C-zeta-1
UniProt Gene Name
PLCZ1
UniProt Synonym Gene Names
PLC-zeta-1
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

NCBI Summary for PLCZ1

The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
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UniProt Comments for PLCZ1

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLCZ1 antibody

 Reference Product  PubMed Publications
 ITPR1 antibody  >2 publications with PLCZ1 and ITPR1

Diseases associated with anti-PLCZ1 antibody

Organs/Tissues associated with anti-PLCZ1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >7 publications with PLCZ1 and Testis
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