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ACER2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS859869

Rabbit polyclonal ACER2 (1) antibody was raised against a peptide from intermediate residues of human ACER2 protein. More details

$430 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ACER2, Polyclonal Antibody
Full Product Name
ACER2 Antibody
Product Gene Name
anti-ACER2 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Purified by peptide affinity column containing 0.5% BSA and 0.02% NaN3
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Molecular Weight
15,864 Da
OMIM
613492
3D Structure
ModBase 3D Structure for Q5QJU3

Product Categories/Family for anti-ACER2 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ACER2 antibody
Peptide ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-ACER2 antibody
Peptide ELISA: 1:10,000-1:80,000
IHC: 1:100-500

Testing Data of anti-ACER2 antibody

Rabbit Anti-ACER2 Polyclonal Antibody – Cat# MBS859869

Product References and Citations for anti-ACER2 antibody

(1) Rose, J.E., Behm, F.M., Drgon, T., et al.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Mol. Med. 16 (7-8), 247-253 (2010).

Other Notes

Small volumes of anti-ACER2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACER2 purchase

MBS859869 is an antibody targeting ACER2. Also known as ACER2 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACER2. It may not necessarily be applicable to this product.

NCBI GI #
71043498
NCBI GeneID
340485
NCBI Accession #
NP_001010887.2
UniProt Primary Accession #
Q5QJU3
UniProt Secondary Accession #
Q569G5; Q5VZR7; Q71RD2; A2A3R8
UniProt Related Accession #
Q5QJU3
GenBank Nucleotide #
NM_001010887.2
NCBI Official Full Name
alkaline ceramidase 2
NCBI Official Synonym Full Names
alkaline ceramidase 2
NCBI Official Symbol
ACER2
NCBI Official Synonym Symbols
ASAH3L; ALKCDase2
UniProt Protein Name
Alkaline ceramidase 2
UniProt Synonym Protein Names
Acylsphingosine deacylase 3-like; N-acylsphingosine amidohydrolase 3-like
Protein Family
Alkaline ceramidase
UniProt Gene Name
ACER2
UniProt Synonym Gene Names
ASAH3L; AlkCDase 2; Alkaline CDase 2; haCER2
NCBI Protein Information
alkaline ceramidase 2

NCBI Summary for ACER2

The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010]
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UniProt Comments for ACER2

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)-ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)-ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.
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Research Articles on ACER2

1. Results suggest that the ACER2/sphingosine pathway mediates programmed cell death in response to DNA damage through ROS production.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ACER2 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid De Novo Biosynthesis Pathway antibodies  Sphingolipid De Novo Biosynthesis Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingosine Biosynthesis Pathway antibodies  Sphingosine Biosynthesis Pathway Diagram
 Sphingosine Biosynthesis Pathway antibodies  Sphingosine Biosynthesis Pathway Diagram
 Sphingosine And Sphingosine-1-phosphate Metabolism Pathway antibodies  Sphingosine And Sphingosine-1-phosphate Metabolism Pathway Diagram

Diseases associated with anti-ACER2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with ACER2 and Neoplasms
 Fatty Liver Antibodies  >2 publications with ACER2 and Fatty Liver
 Skin Neoplasms Antibodies  >1 publications with ACER2 and Skin Neoplasms
 Brain Diseases Antibodies  >1 publications with ACER2 and Brain Diseases
 Liver Diseases Antibodies  >1 publications with ACER2 and Liver Diseases

Organs/Tissues associated with anti-ACER2 antibody

 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >2 publications with ACER2 and Placenta
 Blood Antibodies  >1 publications with ACER2 and Blood
 Muscle Antibodies  >1 publications with ACER2 and Muscle
 Vascular Antibodies  >1 publications with ACER2 and Vascular
 Embryonic Tissue Antibodies  >1 publications with ACER2 and Embryonic Tissue
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