Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2) ELISA Kit for Human

Name: Human NR4A2 ELISA Kit; Nuclear Receptor Subfamily 4, Group A, Member 2; MyBioSource
Brand: MyBioSource
SKU: MBS912795
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS912795

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for NR4A2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any NR4A2 present is bound by the… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

nuclear receptor subfamily 4, group A, member 2 (NR4A2), ELISA Kit

Full Product Name

Human Nuclear receptor subfamily 4 group A member 2, NR4A2 ELISA Kit

Product Gene Name

NR4A2 elisa kit

Product Synonym Names

Human Nuclear receptor subfamily 4 group A member 2 (NR4A2) ELISA kit; HZF-3; NOT; NURR1; RNR1; TINUR; NGFI-B/nur77 beta-type transcription factor homolog; OTTHUMP00000204707; T-cell nuclear receptor NOT; intermediate-early receptor protein; nur related protein-1; human ho; nuclear receptor subfamily 4; group A; member 2

Species Reactivity

Human

Assay Type

Quantitative Sandwich

Samples

Serum, plasma, tissue homogenates, cell lysates

Detection Range

31.25 pg/ml-2000 pg/ml

Sensitivity

< 7.81 pg/ml

Specificity

This assay has high sensitivity and excellent specificity for detection of human NR4A2. No significant cross-reactivity or interference between human NR4A2 and analogues was observed.

Preparation and Storage

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Inter-assay Precision

Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

Intra-assay Precision

Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.

Molecular Weight

66,591 Da

OMIM

601828

3D Structure

ModBase 3D Structure for P43354

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NR4A2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NR4A2 purchase

MBS912795 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the nuclear receptor subfamily 4, group A, member 2 (NR4A2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NR4A2. The ELISA analytical biochemical technique of the MBS912795 kit is based on NR4A2 antibody-NR4A2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NR4A2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NR4A2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for NR4A2. It may not necessarily be applicable to this product.

NCBI GI #

5453822

NCBI GeneID

4929

NCBI Accession #

NP_006177.1

UniProt Primary Accession #

P43354

UniProt Secondary Accession #

Q16311; Q53RZ2

UniProt Related Accession #

P43354

GenBank Nucleotide #

NM_006186.3

NCBI Official Full Name

nuclear receptor subfamily 4 group A member 2

NCBI Official Synonym Full Names

nuclear receptor subfamily 4, group A, member 2

NCBI Official Symbol

NR4A2

NCBI Official Synonym Symbols

NOT; RNR1; HZF-3; NURR1; TINUR

UniProt Protein Name

Nuclear receptor subfamily 4 group A member 2

UniProt Synonym Protein Names

Immediate-early response protein NOT; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor

Protein Family

Nuclear receptor subfamily

UniProt Gene Name

NR4A2

UniProt Synonym Gene Names

NOT; NURR1; TINUR

UniProt Entry Name

NR4A2_HUMAN

NCBI Protein Information

nuclear receptor subfamily 4 group A member 2; nuclear receptor related 1; T-cell nuclear receptor NOT; orphan nuclear receptor NR4A2; orphan nuclear receptor NURR1; intermediate-early receptor protein; immediate-early response protein NOT; nur related protein-1, human homolog of; transcriptionally-inducible nuclear receptor; NGFI-B/nur77 beta-type transcription factor homolog; transcriptionally inducible nuclear receptor related 1

NCBI Summary for NR4A2

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

UniProt Comments for NR4A2

NR4A2: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Belongs to the nuclear hormone receptor family. NR4 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 2q22-q23

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor activity; zinc ion binding; protein heterodimerization activity; steroid hormone receptor activity

Biological Process: positive regulation of catalytic activity; transcription initiation from RNA polymerase II promoter; response to inorganic substance; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; adult locomotory behavior; death; regulation of dopamine metabolic process; response to amphetamine; neuron migration; central nervous system projection neuron axonogenesis; dopamine biosynthetic process; response to insecticide; signal transduction; neuron maturation; post-embryonic development; habenula development; regulation of respiratory gaseous exchange; general adaptation syndrome; cellular response to extracellular stimulus; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; negative regulation of neuron apoptosis

Disease: Parkinson Disease, Late-onset

Research Articles on NR4A2

1. Data indicate that expression of Nurr1 was significantly induced by 1,1-bis(3'-indolyl)-1-(p-chlorophenyl methane) (DIM-D).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NR4A2 elisa kit

Reference Product	PubMed Publications
RXRB elisa kit	>1 publications with NR4A2 and RXRB
CDKN1C elisa kit	>1 publications with NR4A2 and CDKN1C

Pathways associated with NR4A2 elisa kit

Products by Pathway	Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Nuclear Receptor Transcription Pathway antibodies	Nuclear Receptor Transcription Pathway Diagram
Nuclear Receptors Pathway antibodies	Nuclear Receptors Pathway Diagram

Diseases associated with NR4A2 elisa kit

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>106 publications with NR4A2 and Nervous System Diseases
Brain Diseases Antibodies	>97 publications with NR4A2 and Brain Diseases
Movement Disorders Antibodies	>69 publications with NR4A2 and Movement Disorders
Neoplasms Antibodies	>46 publications with NR4A2 and Neoplasms
Mental Disorders Antibodies	>39 publications with NR4A2 and Mental Disorders
Disease Models, Animal Antibodies	>25 publications with NR4A2 and Disease Models, Animal
Inflammation Antibodies	>23 publications with NR4A2 and Inflammation
Cardiovascular Diseases Antibodies	>18 publications with NR4A2 and Cardiovascular Diseases
Necrosis Antibodies	>13 publications with NR4A2 and Necrosis
Kidney Diseases Antibodies	>13 publications with NR4A2 and Kidney Diseases

Organs/Tissues associated with NR4A2 elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>222 publications with NR4A2 and Brain
Nerve Antibodies	>123 publications with NR4A2 and Nerve
Thyroid Antibodies	>50 publications with NR4A2 and Thyroid
Embryonic Tissue Antibodies	>37 publications with NR4A2 and Embryonic Tissue
Blood Antibodies	>36 publications with NR4A2 and Blood
Kidney Antibodies	>24 publications with NR4A2 and Kidney
Muscle Antibodies	>22 publications with NR4A2 and Muscle
Vascular Antibodies	>19 publications with NR4A2 and Vascular
Liver Antibodies	>16 publications with NR4A2 and Liver
Adrenal Gland Antibodies	>15 publications with NR4A2 and Adrenal Gland