Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 1 (HSP90AB1) ELISA Kit for Mouse

HSP90B: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4. Belongs to the heat shock protein 90 family.

Protein type: Heat shock protein; Chaperone

Cellular Component: signalosome; cell surface; mitochondrion; membrane; brush border membrane; basolateral plasma membrane; apical plasma membrane; cytoplasm; intracellular; inclusion body; cytosol

Molecular Function: protein binding; GTP binding; double-stranded RNA binding; unfolded protein binding; dATP binding; nucleotide binding; sulfonylurea receptor binding; protein kinase binding; kinase binding; ATP binding

Biological Process: positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; protein folding; positive regulation of cell size; response to stress; negative regulation of neuron apoptosis; placenta development