Glucocorticoid Induced Tumor Necrosis Factor Receptor (GITR) ELISA Kit for Rabbit

Name: Rabbit GITR ELISA Kit; MyBioSource
Brand: MyBioSource
SKU: MBS093468
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS093468

MBS093468 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Glucocorticoid Induced Tumor Necrosis Factor Receptor (GITR) ELISA Kit target analytes in biological samples. The… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Glucocorticoid Induced Tumor Necrosis Factor Receptor (GITR), ELISA Kit

Full Product Name

Rabbit Glucocorticoid Induced Tumor Necrosis Factor Receptor ELISA Kit

Product Gene Name

GITR elisa kit

Species Reactivity

Rabbit

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

26,000 Da

OMIM

603905

3D Structure

ModBase 3D Structure for Q9Y5U5

Other Notes

Small volumes of GITR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GITR. It may not necessarily be applicable to this product.

NCBI GI #

4558503

NCBI GeneID

8784

NCBI Accession #

AAD22635.1

UniProt Primary Accession #

Q9Y5U5

UniProt Secondary Accession #

O95851; Q5U0I4; Q9NYJ9; B1AME1

UniProt Related Accession #

Q9Y5U5

NCBI Official Full Name

glucocorticoid-induced TNFR-related protein

NCBI Official Synonym Full Names

tumor necrosis factor receptor superfamily, member 18

NCBI Official Symbol

TNFRSF18

NCBI Official Synonym Symbols

AITR; GITR; CD357; GITR-D

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 18

UniProt Synonym Protein Names

Activation-inducible TNFR family receptor; Glucocorticoid-induced TNFR-related protein

UniProt Gene Name

TNFRSF18

UniProt Synonym Gene Names

AITR; GITR

UniProt Entry Name

TNR18_HUMAN

NCBI Protein Information

tumor necrosis factor receptor superfamily member 18; activation-inducible TNFR family receptor; glucocorticoid-induced TNFR-related protein; TNF receptor superfamily activation-inducible protein

NCBI Summary for GITR

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

UniProt Comments for GITR

TNFRSF18: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Receptor, cytokine

Chromosomal Location of Human Ortholog: 1p36.3

Cellular Component: integral to plasma membrane; extracellular region; external side of plasma membrane

Molecular Function: tumor necrosis factor receptor activity

Biological Process: tumor necrosis factor-mediated signaling pathway; apoptosis; signal transduction; negative regulation of apoptosis

Research Articles on GITR

1. these results show a higher susceptibility to apoptosis in patients' versus controls' T(reg) cells, suggesting that GITR is a T(reg)-cell marker that would be primarily involved in T(reg)-cell survival rather than in their suppressor function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GITR elisa kit

Reference Product	PubMed Publications
FOXP3 elisa kit	>130 publications with GITR and FOXP3
CTLA4 elisa kit	>74 publications with GITR and CTLA4
IL2RA elisa kit	>66 publications with GITR and IL2RA
TNFSF18 elisa kit	>51 publications with GITR and TNFSF18
IL2RB elisa kit	>17 publications with GITR and IL2RB
TRAF2 elisa kit	>3 publications with GITR and TRAF2
TRAF1 elisa kit	>2 publications with GITR and TRAF1
IL2RG elisa kit	>1 publications with GITR and IL2RG

Pathways associated with GITR elisa kit

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Downstream Signaling In Naive CD8+ T Cells Pathway antibodies	Downstream Signaling In Naive CD8+ T Cells Pathway Diagram

Diseases associated with GITR elisa kit

Disease Name	Pubmed Publications
Necrosis Antibodies	>255 publications with GITR and Necrosis
Immune System Diseases Antibodies	>83 publications with GITR and Immune System Diseases
Inflammation Antibodies	>48 publications with GITR and Inflammation
Disease Models, Animal Antibodies	>33 publications with GITR and Disease Models, Animal
Carcinoma Antibodies	>13 publications with GITR and Carcinoma
Neoplasms, Experimental Antibodies	>13 publications with GITR and Neoplasms, Experimental
Liver Diseases Antibodies	>9 publications with GITR and Liver Diseases
Nervous System Diseases Antibodies	>8 publications with GITR and Nervous System Diseases
Cardiovascular Diseases Antibodies	>7 publications with GITR and Cardiovascular Diseases
Heart Diseases Antibodies	>4 publications with GITR and Heart Diseases

Organs/Tissues associated with GITR elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>248 publications with GITR and Blood
Lymph Node Antibodies	>31 publications with GITR and Lymph Node
Lung Antibodies	>13 publications with GITR and Lung
Intestine Antibodies	>7 publications with GITR and Intestine
Brain Antibodies	>6 publications with GITR and Brain
Kidney Antibodies	>4 publications with GITR and Kidney