Frizzled-Related (FRZB) ELISA Kit for Mouse

Name: Mouse FRZB ELISA Kit; Frizzled-Related; MyBioSource
Brand: MyBioSource
SKU: MBS937358
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS937358

MBS937358 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the frizzled-related protein (FRZB) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

frizzled-related protein (FRZB), ELISA Kit

Full Product Name

Mouse Secreted frizzled-related protein 3, FRZB ELISA Kit

Product Gene Name

FRZB elisa kit

Product Synonym Names

Mouse Secreted frizzled-related protein 3 (FRZB) ELISA kit; FRE; FRITZ; FRP-3; FRZB-1; FRZB-PEN; FRZB1; FZRB; OS1; SFRP3; SRFP3; hFIZ; frizzled homolog-related; frizzled-related protein

Species Reactivity

Mouse

Specificity

This assay has high sensitivity and excellent specificity for detection of Mouse FRZB. No significant cross-reactivity or interference between Mouse FRZB and analogues was observed.

Preparation and Storage

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Intra-assay Precision

Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.

Molecular Weight

36,011 Da

3D Structure

ModBase 3D Structure for P97401

Detection Wavelength

450 nm

Sample Volume

50-100ul

Protein Biological Process 1

Developmental Protein

Protein Biological Process 3

Differentiation

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of FRZB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FRZB. It may not necessarily be applicable to this product.

NCBI GI #

6755476

NCBI GeneID

20378

NCBI Accession #

NP_035486.1

UniProt Primary Accession #

P97401

UniProt Secondary Accession #

O09075; O09093; Q91W58

UniProt Related Accession #

P97401

GenBank Nucleotide #

NM_011356.4

NCBI Official Full Name

secreted frizzled-related protein 3

NCBI Official Synonym Full Names

frizzled-related protein

NCBI Official Symbol

Frzb

NCBI Official Synonym Symbols

Frp; Sfrp3; fritz; frzb-1; frezzled

UniProt Protein Name

Secreted frizzled-related protein 3

UniProt Synonym Protein Names

Frezzled; Fritz; Frizzled-related protein 1; FrzB-1

Protein Family

Frizzy aggregation protein

UniProt Gene Name

Frzb

UniProt Synonym Gene Names

Fiz; Fre; Frzb1; Sfrp3; sFRP-3

UniProt Entry Name

SFRP3_MOUSE

NCBI Protein Information

secreted frizzled-related protein 3; sFRP-3; frizzled-related protein 1; secreted frizzled-related sequence protein 3

UniProt Comments for FRZB

FRZB: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. Defects in FRZB are associated with susceptibility to osteoarthritis type 1(OS1). Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular space; extracellular region

Molecular Function: Wnt-protein binding; protein binding

Biological Process: negative regulation of cell proliferation; inner ear morphogenesis; convergent extension involved in organogenesis; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; positive regulation of apoptosis; multicellular organismal development; positive regulation of fat cell differentiation; negative regulation of cell growth; cell differentiation

Research Articles on FRZB

1. left ventricles from post-MI mice showed an increased sFRP3 mRNA level, particularly in cardiac fibroblasts, and (iv) mechanical stretch enhanced sFRP3 expression and release in myocardial fibroblasts

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FRZB elisa kit

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Endochondral Ossification Pathway antibodies	Endochondral Ossification Pathway Diagram

Diseases associated with FRZB elisa kit

Disease Name	Pubmed Publications
Osteoarthritis Antibodies	>38 publications with FRZB and Osteoarthritis
Disease Models, Animal Antibodies	>10 publications with FRZB and Disease Models, Animal
Breast Neoplasms Antibodies	>5 publications with FRZB and Breast Neoplasms
Adenocarcinoma Antibodies	>5 publications with FRZB and Adenocarcinoma
Kidney Neoplasms Antibodies	>4 publications with FRZB and Kidney Neoplasms
Inflammation Antibodies	>4 publications with FRZB and Inflammation
Kidney Diseases Antibodies	>4 publications with FRZB and Kidney Diseases
Brain Diseases Antibodies	>4 publications with FRZB and Brain Diseases
Neoplasm Metastasis Antibodies	>3 publications with FRZB and Neoplasm Metastasis
Liver Neoplasms Antibodies	>3 publications with FRZB and Liver Neoplasms

Organs/Tissues associated with FRZB elisa kit

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>39 publications with FRZB and Embryonic Tissue
Eye Antibodies	>12 publications with FRZB and Eye
Brain Antibodies	>11 publications with FRZB and Brain
Kidney Antibodies	>10 publications with FRZB and Kidney
Lung Antibodies	>8 publications with FRZB and Lung
Heart Antibodies	>6 publications with FRZB and Heart
Stomach Antibodies	>6 publications with FRZB and Stomach
Skin Antibodies	>4 publications with FRZB and Skin
Inner Ear Antibodies	>4 publications with FRZB and Inner Ear
Dorsal Root Ganglion Antibodies	>3 publications with FRZB and Dorsal Root Ganglion