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Protein CASP (CUX1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS948650

MBS948650 is a recombinant protein targeting Cux1. Also known as Recombinant Mouse Protein CASP (Cux1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Protein CASP (Cux1), Recombinant Protein
Full Product Name
Recombinant Mouse Protein CASP (Cux1)
Product Gene Name
Cux1 recombinant protein
Product Synonym Gene Name
Cux1; Cutl1
Product Synonym Names
Protein CASP
Sequence
MAANVGSMSQ YWKRFDLQQL QRELDAAATV LANRQDESEQ SRKRLIEQSR EFKKNTPEDL RKQVAPLLKS FQGEIDALSK RSKEAEAAFL TVYKRLIDVP DPVPALDVGQ QLEIKVQRLH DIETENQKLR ETLEEYNKEF AEVKNQEVTI KALKEKIREY EQTLKSQAET IALEKEQKLQ NDFAEKERKL QETQMSTTSK LEEAEHKLQT LQTALEKTRT ELFDLKTKYD EETTAKADEI EMIMTDLERA NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVEQA IEVLTRSSLE VELAAKEREI AQLVEDVQRL QASLTKLREN SASQISQLEQ QLNAKNSTLK QLEEKLKGQA DYEEVKKELN TLKSMEFAPS EGAGTQDSTK PLEVLLLEKN RSLQSENATL RISNSDLSGR CAELQIHLTE ATAKAVEQKE LIARLEQDLS TIQSIQRPDA EGASEQGLEK IPEPIKEATA LFYGPSMSSS GTLPEGQVDS LLSIISSQRE RFRTRNQELE AESRMAQHTI QALQSELDSL RADNIKLFEK IKFLQSYPGR GIGSDDTELR YSSQYEERLD PFSSFSKRER QRKYLGLSPW DKATLGMGRL ILSNKTART
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
165,596 Da
Sequence Positions
1-619
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P70403
Species
Mus musculus (Mouse)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Cux1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Cux1. It may not necessarily be applicable to this product.

NCBI GI #
85720588
NCBI GeneID
13047
NCBI Accession #
P70403.2
UniProt Primary Accession #
P70403
UniProt Secondary Accession #
Q7TQJ4; Q91WN6
UniProt Related Accession #
P53564; P70403
NCBI Official Full Name
Protein CASP
NCBI Official Synonym Full Names
cut-like homeobox 1
NCBI Official Symbol
Cux1
NCBI Official Synonym Symbols
CDP; Cux; Cutl1; Cux-1
UniProt Protein Name
Protein CASP
Protein Family
Homeobox protein
UniProt Gene Name
Cux1
UniProt Synonym Gene Names
Cutl1
UniProt Entry Name
CASP_MOUSE
NCBI Protein Information
protein CASP; cut-like 1; Cux/CDP homeoprotein; homeobox protein cux-1; CCAAT displacement protein; homeobox protein cut-like 1

UniProt Comments for Cux1

CUTL1 iso7: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Belongs to the CUT homeobox family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Membrane protein, integral; Transcription factor

Cellular Component: Golgi apparatus; membrane; cytoplasm; integral to membrane; integral to Golgi membrane; nucleus

Molecular Function: DNA binding; sequence-specific DNA binding; chromatin binding

Biological Process: transcription from RNA polymerase II promoter; intra-Golgi vesicle-mediated transport; transcription, DNA-dependent; regulation of transcription, DNA-dependent; transport; multicellular organismal development; auditory receptor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter; kidney development; lung development
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Research Articles on Cux1

1. overexpression of active CUTL1 significantly resulted in increased cancer tissue response to chemotherapy and therefore inhibited growth, whereas knockdown of CUTL1 conferred resistance to chemotherapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Cux1 recombinant protein

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 PodNet: Protein-protein Interactions In The Podocyte Pathway antibodies  PodNet: Protein-protein Interactions In The Podocyte Pathway Diagram
 Signaling By FGFR In Disease Pathway antibodies  Signaling By FGFR In Disease Pathway Diagram
 Signaling By FGFR Mutants Pathway antibodies  Signaling By FGFR Mutants Pathway Diagram
 Signaling By FGFR1 Fusion Mutants Pathway antibodies  Signaling By FGFR1 Fusion Mutants Pathway Diagram
 Signaling By FGFR1 Mutants Pathway antibodies  Signaling By FGFR1 Mutants Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram

Diseases associated with Cux1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >36 publications with Cux1 and Neoplasms
 Breast Neoplasms Antibodies  >10 publications with Cux1 and Breast Neoplasms
 Neoplasm Invasiveness Antibodies  >8 publications with Cux1 and Neoplasm Invasiveness
 Kidney Diseases Antibodies  >8 publications with Cux1 and Kidney Diseases
 Carcinoma Antibodies  >6 publications with Cux1 and Carcinoma
 Pancreatic Neoplasms Antibodies  >6 publications with Cux1 and Pancreatic Neoplasms
 Uterine Neoplasms Antibodies  >5 publications with Cux1 and Uterine Neoplasms
 Inflammation Antibodies  >5 publications with Cux1 and Inflammation
 Adenocarcinoma Antibodies  >4 publications with Cux1 and Adenocarcinoma
 Nervous System Diseases Antibodies  >4 publications with Cux1 and Nervous System Diseases

Organs/Tissues associated with Cux1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23 publications with Cux1 and Brain
 Kidney Antibodies  >11 publications with Cux1 and Kidney
 Embryonic Tissue Antibodies  >9 publications with Cux1 and Embryonic Tissue
 Lung Antibodies  >7 publications with Cux1 and Lung
 Liver Antibodies  >5 publications with Cux1 and Liver
 Bone Marrow Antibodies  >3 publications with Cux1 and Bone Marrow
 Mammary Gland Antibodies  >3 publications with Cux1 and Mammary Gland
 Thymus Antibodies  >3 publications with Cux1 and Thymus
 Heart Antibodies  >3 publications with Cux1 and Heart
 Spleen Antibodies  >3 publications with Cux1 and Spleen
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