Rat APBB1 Recombinant Protein – Cat# MBS951638

Amyloid Beta A4 Precursor Protein-Binding Family B Member 1 (APBB1) Rat Recombinant Protein

Name: APBB1 Recombinant Protein; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS951638
Price: 1555 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS951638

This protein is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer s disease amyloid precursor protein (APP), transcription factor CP2LSFLBP1 and the low-density lipoprotein receptor-related… More details

$1555 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Amyloid beta A4 precursor protein-binding family B member 1 (Apbb1), Recombinant Protein

Full Product Name

Recombinant Rat Amyloid beta A4 precursor protein-binding family B member 1 (Apbb1)

Product Gene Name

Apbb1 recombinant protein

Sequence

MSVPSSLSQS AINANSHGGP ALSFPFPLHA AHNQLLNAKL QATAVVPKDL RSAMGEGSVP EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS QEAETAPLGP KGLMHLYSEL ELSAHNAANR GLHGSALIIN TQGLGPDEGE EKAAGEVEEE DEDEEEEDEE EEDLSSPQGL PEPLENVEVP SGPQVLTDGP REHSKSASLL FGMRNSAASD EDSSWATLSQ GSPSYGSPED TDSFWNPNAF ETDSDLPAGW MRVQDTSGTY YWHIPTGTTQ WEPPGRASPS QGNSPQEESQ LTWTGFAHQE GFEEGEFWKD EPSEEAPMEL GLKDPEEGTL PFSAQSLSPE PVPQEEENLP QRNANPGIKC FAVRSLGWVE MTEEELAPGR SSVAVNNCIR QLSYHKNNLH DPMSGGWGEG KDLLLQLEDE TLKLVEPQNQ TLLHAQPIVS IRVWGVGRDS GRERDFAYVA RDKLTQMLKC HVFRCEAPAK NIATSLHEIC SKIMSERRNA RCLVNGLSLD HSKLVDVPFQ VEFPAPKNEL VQKFQVYYLG NVPVAKPVGV DVINGALESV LSSSSREQWT PSHVSVAPAT LTILHQQTEA VLGECRVRFL SFLAVGRDVH TFAFIMAAGP ASFCCHMFWC EPNAASLSEA VQAACMLRYQ KCLDARSQTS TSCLPAPPAE SVARRVGWTV RRGVQSLWGS LKPKRLGSQT P

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

77,371 Da

Sequence Positions

1-711, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P46933

Species

Rat

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Apbb1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Apbb1 purchase

MBS951638 is a recombinant protein targeting Apbb1. Also known as Recombinant Rat Amyloid beta A4 precursor protein-binding family B member 1 (Apbb1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Apbb1. It may not necessarily be applicable to this product.

NCBI GI #

17978453

NCBI GeneID

29722

NCBI Accession #

NP_536726.1

UniProt Primary Accession #

P46933

UniProt Secondary Accession #

Q99MK3

UniProt Related Accession #

P46933

GenBank Nucleotide #

NM_080478.1

NCBI Official Full Name

amyloid-beta A4 protein-binding family B member 1

NCBI Official Synonym Full Names

amyloid beta precursor protein binding family B member 1

NCBI Official Symbol

Apbb1

NCBI Official Synonym Symbols

FE65

UniProt Protein Name

Amyloid-beta A4 precursor protein-binding family B member 1

UniProt Synonym Protein Names

Protein Fe65

Protein Family

Amyloid beta A4 precursor protein-binding family

UniProt Gene Name

Apbb1

UniProt Synonym Gene Names

Fe65

NCBI Protein Information

amyloid-beta A4 precursor protein-binding family B member 1; amyloid beta A4 precursor protein-binding family B member 1

NCBI Summary for Apbb1

displays in vitro binding to the NPTY intracellular domain of the Alzheimers disease associated human beta amyloid precursor protein [RGD, Feb 2006]

UniProt Comments for Apbb1

Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).

Research Articles on Apbb1

1. Fe65 is the bridging protein to amyloid-beta protein precursor in the complex formed and thus we simultaneously describe another PP1 binding protein

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Apbb1 recombinant protein

Reference Product	PubMed Publications
App recombinant protein	>109 publications with Apbb1 and App
Kat5 recombinant protein	>17 publications with Apbb1 and Kat5
Aplp1 recombinant protein	>16 publications with Apbb1 and Aplp1
Apoe recombinant protein	>9 publications with Apbb1 and Apoe
Bace1 recombinant protein	>8 publications with Apbb1 and Bace1
Notch1 recombinant protein	>4 publications with Apbb1 and Notch1
Mapk8ip1 recombinant protein	>3 publications with Apbb1 and Mapk8ip1
Pid1 recombinant protein	>3 publications with Apbb1 and Pid1
P2rx2 recombinant protein	>1 publications with Apbb1 and P2rx2
Vldlr recombinant protein	>1 publications with Apbb1 and Vldlr

Pathways associated with Apbb1 recombinant protein

Products by Pathway	Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram

Diseases associated with Apbb1 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>50 publications with Apbb1 and Nervous System Diseases
Disease Models, Animal Antibodies	>5 publications with Apbb1 and Disease Models, Animal
Memory Disorders Antibodies	>3 publications with Apbb1 and Memory Disorders
Learning Disorders Antibodies	>3 publications with Apbb1 and Learning Disorders
Necrosis Antibodies	>3 publications with Apbb1 and Necrosis
Nerve Degeneration Antibodies	>2 publications with Apbb1 and Nerve Degeneration
Cognition Disorders Antibodies	>2 publications with Apbb1 and Cognition Disorders
Lung Diseases Antibodies	>2 publications with Apbb1 and Lung Diseases
Movement Disorders Antibodies	>1 publications with Apbb1 and Movement Disorders
Inflammation Antibodies	>1 publications with Apbb1 and Inflammation

Organs/Tissues associated with Apbb1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>54 publications with Apbb1 and Brain