Adenosine Receptor A2a (ADORA2A) Rat Recombinant Protein

ADORA2A: one of several receptor subtypes for adenosine. A G-protein coupled receptor. Activation is mediated by G proteins which activate adenylyl cyclase. Abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: integral to plasma membrane; postsynaptic density; dendrite; integral to membrane; intermediate filament; endomembrane system; axolemma; Golgi membrane; presynaptic membrane; asymmetric synapse; postsynaptic membrane; membrane; cell soma; axon; plasma membrane; presynaptic active zone

Molecular Function: identical protein binding; protein binding; enzyme binding; protein heterodimerization activity; type 5 metabotropic glutamate receptor binding; adenosine receptor activity, G-protein coupled; alpha-actinin binding

Biological Process: response to alkaloid; positive regulation of circadian sleep/wake cycle, sleep; synaptic transmission, dopaminergic; prepulse inhibition; positive regulation of glutamate secretion; regulation of synaptic plasticity; locomotory behavior; negative regulation of caspase activity; vasodilation; G-protein signaling, adenylate cyclase activating pathway; positive regulation of synaptic transmission, glutamatergic; synaptic transmission, cholinergic; response to caffeine; negative regulation of cell proliferation; regulation of inhibitory postsynaptic membrane potential; negative regulation of alpha-beta T cell activation; negative regulation of locomotion; regulation of mitochondrial membrane potential; regulation of transcription, DNA-dependent; protein kinase C activation; positive regulation of cAMP biosynthetic process; negative regulation of neuron apoptosis; adenosine receptor signaling pathway; positive regulation of acetylcholine secretion; response to drug; synaptic transmission, glutamatergic; eating behavior; response to amphetamine; positive regulation of synaptic transmission, GABAergic; regulation of calcium ion transport; regulation of norepinephrine secretion; G-protein coupled receptor protein signaling pathway; membrane depolarization; positive regulation of protein secretion; negative regulation of inflammatory response; negative regulation of vascular permeability; negative regulation of protein kinase activity; regulation of excitatory postsynaptic membrane potential; astrocyte activation; neurite morphogenesis