Nidogen-1 (NID1) Mouse Recombinant Protein

Sulfated glycoprotein widely distributed in basent membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.

Amino acid sequence and domain structure of entactin. Homology with epidermal growth factor precursor and low density lipoprotein receptor.Durkin M.E., Chakravarti S., Bartos B.B., Liu S.H., Friedman R.L., Chung A.E.J. Cell Biol. 107:2749-2756(1988) Amino acid sequence of mouse nidogen, a multidomain basement membrane protein with binding activity for laminin, collagen IV and cells.Mann K., Deutzmann R., Aumailley M., Timpl R., Raimondi L., Yamamda Y., Pan T.-C., Conway D., Chu M.-L.EMBO J. 8:65-72(1989) Characterization of the 5' end of the mouse Ent gene encoding the basement membrane protein, entactin.Durkin M.E., Liu S.H., Reing J., Chung A.E.Gene 132:261-266(1993) Exon organization of the mouse entactin gene corresponds to the structural domains of the polypeptide and has regional homology to the low-density lipoprotein receptor gene.Durkin M.E., Wewer U.M., Chung A.E.Genomics 26:219-228(1995) Purification and structural characterization of intact and fragmented nidogen obtained from a tumor basement membrane.Paulsson M., Deutzmann R., Dziadek M., Nowack H., Timpl R., Weber S., Engel J.Eur. J. Biochem. 156:467-478(1986) Structure and localization of O- and N-linked oligosaccharide chains on basement membrane protein nidogen.Fujiwara S., Shinkai H., Mann K., Timpl R.Matrix 13:215-222(1993) Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules.Adam S., Goehring W., Wiedemann H., Chu M.-L., Timpl R., Kostka G.J. Mol. Biol. 272:226-236(1997) Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.Sasaki T., Brakebusch C., Engel J., Timpl R.EMBO J. 17:1606-1613(1998) Recombinant domains of mouse nidogen-1 and their binding to basement membrane proteins and monoclonal antibodies.Ries A., Goehring W., Fox J.W., Timpl R., Sasaki T.Eur. J. Biochem. 268:5119-5128(2001) Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo.Lee H.K., Seo I.A., Park H.K., Park H.T.FEBS Lett. 580:2253-2257(2006) Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1.Hopf M., Gohring W., Ries A., Timpl R., Hohenester E.Nat. Struct. Biol. 8:634-640(2001)

Small volumes of Nid1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS954331 is a recombinant protein targeting Nid1. Also known as Recombinant Mouse Nidogen-1. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.