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Annexin A1 (ANXA1) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS954685

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It ses to bind from two to four calcium ions with high affinity. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Annexin A1 (Anxa1), Recombinant Protein
Full Product Name
Recombinant Mouse Annexin A1
Product Gene Name
Anxa1 recombinant protein
Product Synonym Gene Name
Anx1; Lpc-1; Lpc1
Product Synonym Names
Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35
Sequence
AMVSEFLKQA RFLENQEQEY VQAVKSYKGG PGSAVSPYPS FNVSSDVAAL HKAIMVKGVD EATIIDILTK RTNAQRQQIK AAYLQENGKP LDEVLRKALT GHLEEVVLAM LKTPAQFDAD ELRGAMKGLG TDEDTLIEIL TTRSNEQIRE INRVYREELK RDLAKDITSD TSGDFRKALL ALAKGDRCQD LSVNQDLADT DARALYEAGE RRKGTDVNVF TTILTSRSFP HLRRVFQNYG KYSQHDMNKA LDLELKGDIE KCLTTIVKCA TSTPAFFAEK LYEAMKGAGT RHKALIRIMV SRSEIDMNEI KVFYQKKYGI SLCQAILDET KGDYEKILVA LCGGN
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
40.6 kDa
Sequence Positions
2-346aa; Full Length of Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P10107
Buffer
0.2um sterile filtered 20 mM Tris-HCl, 0.5M NaCl, pH 8.0, 50% glycerol
Production Note
Special Offer: The E Coli, Yeast host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Coli, Yeasthost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli, Yeast host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli, Yeast host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of Anxa1 recombinant protein

Mouse ANXA1 Recombinant Protein – Cat# MBS954685

Product References and Citations for Anxa1 recombinant protein

Mouse lipocortin I cDNA.Sakata T., Iwagami S., Tsuruta Y., Suzuki R., Hojo K., Sato K., Teraoka H.Nucleic Acids Res. 16:11818-11818(1988) Mouse lipocortin I gene structure and chromosomal assignment gene duplication and the origins of a gene family.Horlick K.R., Cheng I.C., Wong W.T., Wakeland E.K., Nick H.S.Genomics 10:365-374(1991) cDNA-cloning, sequencing and expression in glucocorticoid-stimulated quiescent Swiss 3T3 fibroblasts of mouse lipocortin I.Philipps C., Rose-John S., Rincke G., Fuerstenberger G., Marks F.Biochem. Biophys. Res. Commun. 159:155-162(1989) Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing.Lennon N.J., Kho A., Bacskai B.J., Perlmutter S.L., Hyman B.T., Brown R.H. Jr.J. Biol. Chem. 278:50466-50473(2003) Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.Mol. Cell. Proteomics 8:904-912(2009) SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.Mol. Cell 50:919-930(2013)

Other Notes

Small volumes of Anxa1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Anxa1 purchase

MBS954685 is a recombinant protein targeting Anxa1. Also known as Recombinant Mouse Annexin A1. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Anxa1. It may not necessarily be applicable to this product.

NCBI GI #
124517663
NCBI GeneID
16952
NCBI Accession #
NP_034860.2
UniProt Primary Accession #
P10107
UniProt Related Accession #
P10107
GenBank Nucleotide #
NM_010730.2
NCBI Official Full Name
annexin A1
NCBI Official Synonym Full Names
annexin A1
NCBI Official Symbol
Anxa1
NCBI Official Synonym Symbols
Lpc1; Anx-1; Lpc-1; Anx-A1; C430014K04Rik
UniProt Protein Name
Annexin A1
UniProt Synonym Protein Names
Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I
Protein Family
Annexin
UniProt Gene Name
Anxa1
UniProt Synonym Gene Names
Anx1; Lpc-1; Lpc1
UniProt Entry Name
ANXA1_MOUSE
NCBI Protein Information
annexin A1

UniProt Comments for Anxa1

ANXA1: a calcium/phospholipid-binding protein with which promotes membrane fusion and is involved in endocytosis. Has anti-inflammatory properties and inhibits phospholipase A2 activity. Accumulates on internalized vesicles after EGF-stimulated endocytosis, suggesting that it may be required for a late stage in inward vesiculation. Phosphorylated by PKC, EGFR and Chak1. Phosphorylation results in loss of the inhibitory activity. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Calcium-binding; Lipid-binding

Cellular Component: apical plasma membrane; cell projection; cell surface; cilium; cornified envelope; cytoplasm; cytoplasmic vesicle; endosome; extracellular region; extracellular space; extrinsic to external side of plasma membrane; extrinsic to membrane; focal adhesion; lateral plasma membrane; mast cell granule; membrane; mitochondrial membrane; nucleoplasm; nucleus; plasma membrane; protein complex; sarcolemma; vesicle

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; double-stranded DNA-dependent ATPase activity; helicase activity; metal ion binding; phospholipase A2 inhibitor activity; phospholipase inhibitor activity; phospholipid binding; protein binding; protein binding, bridging; protein homodimerization activity; single-stranded DNA binding; single-stranded RNA binding; structural molecule activity

Biological Process: actin cytoskeleton reorganization; adaptive immune response; alpha-beta T cell differentiation; arachidonic acid secretion; cell surface receptor linked signal transduction; DNA duplex unwinding; DNA strand renaturation; G-protein signaling, coupled to cyclic nucleotide second messenger; immune system process; inflammatory response; innate immune response; insulin secretion; keratinocyte differentiation; monocyte chemotaxis; myoblast migration involved in skeletal muscle regeneration; negative regulation of exocytosis; negative regulation of protein secretion; negative regulation of T-helper 2 cell differentiation; neutrophil homeostasis; peptide cross-linking; phagocytosis; positive regulation of apoptosis; positive regulation of interleukin-2 production; positive regulation of neutrophil apoptosis; positive regulation of prostaglandin biosynthetic process; positive regulation of T cell proliferation; positive regulation of T-helper 1 cell differentiation; positive regulation of vesicle fusion; regulation of cell proliferation; regulation of cell shape; regulation of hormone secretion; regulation of inflammatory response; regulation of interleukin-1 production; regulation of leukocyte migration; signal transduction
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Research Articles on Anxa1

1. knock-out mice are more susceptible to Mycobacterium tuberculosis infection

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Anxa1 recombinant protein

 Reference Product  PubMed Publications
 Fpr2 recombinant protein  >32 publications with Anxa1 and Fpr2
 Fpr1 recombinant protein  >17 publications with Anxa1 and Fpr1
 S100a11 recombinant protein  >5 publications with Anxa1 and S100a11
 Fpr3 recombinant protein  >4 publications with Anxa1 and Fpr3
 Ptger3 recombinant protein  >2 publications with Anxa1 and Ptger3
 Fpr-rs7 recombinant protein  >1 publications with Anxa1 and Fpr-rs7
 Ednra recombinant protein  >1 publications with Anxa1 and Ednra

Pathways associated with Anxa1 recombinant protein

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway antibodies  Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with Anxa1 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >99 publications with Anxa1 and Inflammation
 Carcinoma Antibodies  >65 publications with Anxa1 and Carcinoma
 Disease Models, Animal Antibodies  >31 publications with Anxa1 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >25 publications with Anxa1 and Neoplasm Metastasis
 Brain Diseases Antibodies  >22 publications with Anxa1 and Brain Diseases
 Carcinoma, Squamous Cell Antibodies  >19 publications with Anxa1 and Carcinoma, Squamous Cell
 Neoplasm Invasiveness Antibodies  >14 publications with Anxa1 and Neoplasm Invasiveness
 Cardiovascular Diseases Antibodies  >14 publications with Anxa1 and Cardiovascular Diseases
 Necrosis Antibodies  >13 publications with Anxa1 and Necrosis
 Stomach Diseases Antibodies  >12 publications with Anxa1 and Stomach Diseases

Organs/Tissues associated with Anxa1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >113 publications with Anxa1 and Blood
 Brain Antibodies  >36 publications with Anxa1 and Brain
 Lung Antibodies  >29 publications with Anxa1 and Lung
 Liver Antibodies  >20 publications with Anxa1 and Liver
 Pituitary Gland Antibodies  >15 publications with Anxa1 and Pituitary Gland
 Muscle Antibodies  >13 publications with Anxa1 and Muscle
 Stomach Antibodies  >13 publications with Anxa1 and Stomach
 Bone Antibodies  >12 publications with Anxa1 and Bone
 Kidney Antibodies  >11 publications with Anxa1 and Kidney
 Heart Antibodies  >9 publications with Anxa1 and Heart
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