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TRAF Family Member-Associated Nf-Kappa-B Activator (TANK) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS956536

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. This protein is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3,… More details

$1220 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TRAF family member-associated NF-kappa-B activator (Tank), Recombinant Protein
Full Product Name
Recombinant Mouse TRAF family member-associated NF-kappa-B activator (Tank)
Product Gene Name
Tank recombinant protein
Sequence
MSLKRHSLRR NACHLETRAG IPTILYSDAT GQRGMDKNIG EQLNRAYEAF RQACMDRDSA VRELQQKQTE NYEQRIREQQ EQLSFQQNLI DRLKSQLLLV DSSRDNSYGY VPLLEDSDRR KNNLTLDEPH DKVKLGTLRD KQSKVRRQEV SSGKESAKGL NIPLHHERDN IEKTFWDLKE EFHRICLLAK AQKDHLSKLN IPDIATDTQC SVPIQCTDKT EKQEALFKPQ AKDDINRGMS CVTAVTPRGL GRDEEDTSFE SLSKFNVKFP PMDNDSIFLH STPEAPSILA PATPETVCQD RFNMEVRDNP GNFVKTEETL FEIQGIDPIT SAIQNLKTTD KTNPSNLRAT CLPAGDHNVF YVNTFPLQDP PDAPFPSLDS PGKAVRGPQQ PFWKPFLNQD TDLVVPSDSD SELLKPLVCE FCQELFPPSI TSRGDFLRHL NTHFNGET
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
44,827 Da
Sequence Positions
1-448, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P70347
Species
Mouse
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Tank recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tank purchase

MBS956536 is a recombinant protein targeting Tank. Also known as Recombinant Mouse TRAF family member-associated NF-kappa-B activator (Tank). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Tank. It may not necessarily be applicable to this product.

NCBI GI #
255759991
NCBI GeneID
21353
NCBI Accession #
NP_001157544.1
UniProt Primary Accession #
P70347
UniProt Secondary Accession #
Q61178
UniProt Related Accession #
P70347
GenBank Nucleotide #
NM_001164072.1
NCBI Official Full Name
TRAF family member-associated NF-kappa-B activator isoform 2
NCBI Official Synonym Full Names
TRAF family member-associated Nf-kappa B activator
NCBI Official Symbol
Tank
NCBI Official Synonym Symbols
C86182; I-TRAF; E430026L09Rik
UniProt Protein Name
TRAF family member-associated NF-kappa-B activator
UniProt Synonym Protein Names
TRAF-interacting protein; I-TRAF
Protein Family
TRAF family member-associated NF-kappa-B activator
UniProt Gene Name
Tank
UniProt Synonym Gene Names
Itraf; I-TRAF
NCBI Protein Information
TRAF family member-associated NF-kappa-B activator

UniProt Comments for Tank

Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus.
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Research Articles on Tank

1. TANK is expressed in DRG neurons. TANK is increased by peripheral nerve injury. the regulation of TANK expression is, at least in part, controlled by the injury-associated transcription factor Sox11.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Tank recombinant protein

 Products by Pathway  Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
 TNF-alpha NF-kB Signaling Pathway antibodies  TNF-alpha NF-kB Signaling Pathway Diagram

Diseases associated with Tank recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >236 publications with Tank and Nervous System Diseases
 Neoplasms Antibodies  >212 publications with Tank and Neoplasms
 Cardiovascular Diseases Antibodies  >163 publications with Tank and Cardiovascular Diseases
 Drug Toxicity Antibodies  >142 publications with Tank and Drug Toxicity
 Vascular Diseases Antibodies  >104 publications with Tank and Vascular Diseases
 Heart Diseases Antibodies  >87 publications with Tank and Heart Diseases
 Necrosis Antibodies  >82 publications with Tank and Necrosis
 Lung Diseases Antibodies  >66 publications with Tank and Lung Diseases
 Brain Diseases Antibodies  >64 publications with Tank and Brain Diseases
 Disease Models, Animal Antibodies  >64 publications with Tank and Disease Models, Animal

Organs/Tissues associated with Tank recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >270 publications with Tank and Brain
 Heart Antibodies  >269 publications with Tank and Heart
 Skin Antibodies  >205 publications with Tank and Skin
 Muscle Antibodies  >177 publications with Tank and Muscle
 Kidney Antibodies  >127 publications with Tank and Kidney
 Lung Antibodies  >122 publications with Tank and Lung
 Eye Antibodies  >93 publications with Tank and Eye
 Bladder Antibodies  >49 publications with Tank and Bladder
 Ovary Antibodies  >30 publications with Tank and Ovary
 Bone Marrow Antibodies  >28 publications with Tank and Bone Marrow
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