SCO6462 Recombinant Protein – Cat# MBS958443

Methylated-DNA--Protein-Cysteine Methyltransferase (SCO6462) Recombinant Protein

Name: SCO6462 Recombinant Protein; MyBioSource
Brand: MyBioSource
SKU: MBS958443
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS958443

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide… More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Methylated-DNA--protein-cysteine methyltransferase (SCO6462), Recombinant Protein

Full Product Name

Recombinant human Methylated-DNA--protein-cysteine methyltransferase

Product Gene Name

SCO6462 recombinant protein

Product Synonym Names

Recombinant human Methylated-DNA--protein-cysteine methyltransferase protein

Sequence

QPAPLERFAS RRPQVLAVRT VCDLVLGKMD KDCEMKRTTL DSPLGKLELS GCEQGLHEIK LLGKGTSAAD AVEVPAPAAV LGGPEPLMQC TAWLNAYFHQ PEAIEEFPVP ALHHPVFQQE SFTRQVLWKL LKVVKFGEVI SYQQLAALAG NPKAARAVGG AMRGNPVPIL IPCHRVVCSS GAVGNYSGGL AVKEWLLAHE GHRLGKPGLG GSSGLAGAWL KGAGATSGSP PAGRN

Host

E Coli

Form/Format

Liquid containing glycerol

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C.

Molecular Weight

28.7 kDa

Sequence Positions

4-238aa; Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Product Categories/Family for SCO6462 recombinant protein

Epigenetics and Nuclear Signaling

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for SCO6462 recombinant protein

[1] "Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine."

Other Notes

Small volumes of SCO6462 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SCO6462 purchase

MBS958443 is a recombinant protein targeting SCO6462. Also known as Recombinant human Methylated-DNA--protein-cysteine methyltransferase. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for SCO6462. It may not necessarily be applicable to this product.

NCBI GI #

21224768

NCBI GeneID

1101901

NCBI Official Full Name

methylated-DNA-protein-cysteine methyltransferase

NCBI Official Symbol

SCO6462

NCBI Official Synonym Symbols

SC9B5.29

Protein Family

Methylated-DNA--protein-cysteine methyltransferase

NCBI Protein Information

methylated-DNA-protein-cysteine methyltransferase

NCBI Summary for SCO6462

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]

Research Articles on SCO6462

1. Low MGMT expression is associated with pituitary adenoma tumor recurrence.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SCO6462 recombinant protein

Reference Product	PubMed Publications
FLNA recombinant protein	>12 publications with SCO6462 and FLNA

Pathways associated with SCO6462 recombinant protein

Products by Pathway	Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram

Organs/Tissues associated with SCO6462 recombinant protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>13 publications with SCO6462 and Bone
Connective Tissue Antibodies	>4 publications with SCO6462 and Connective Tissue
Heart Antibodies	>3 publications with SCO6462 and Heart
Muscle Antibodies	>3 publications with SCO6462 and Muscle
Brain Antibodies	>3 publications with SCO6462 and Brain
Vascular Antibodies	>2 publications with SCO6462 and Vascular
Embryonic Tissue Antibodies	>2 publications with SCO6462 and Embryonic Tissue
Ear Antibodies	>1 publications with SCO6462 and Ear
Kidney Antibodies	>1 publications with SCO6462 and Kidney
Umbilical Cord Antibodies	>1 publications with SCO6462 and Umbilical Cord