ADH5: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Cofactor and Vitamin Metabolism - retinol; Oxidoreductase; EC 1.1.1.284; Lipid Metabolism - fatty acid; EC 1.1.1.1; Mitochondrial; Energy Metabolism - methane; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - tyrosine
Cellular Component: mitochondrion; cytoplasm; nucleus
Molecular Function: mevaldate reductase activity; protein homodimerization activity; zinc ion binding; metal ion binding; oxidoreductase activity; C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity; (R)-2-hydroxyisocaproate dehydrogenase activity; steroid dehydrogenase activity; D-arabinitol dehydrogenase (NADP+) activity; fatty acid binding; acetoin dehydrogenase activity; gluconate dehydrogenase activity; (R)-2-hydroxyglutarate dehydrogenase activity; phenylcoumaran benzylic ether reductase activity; aldo-keto reductase activity; formaldehyde dehydrogenase activity; alcohol dehydrogenase activity; isocitrate dehydrogenase activity; arabinose reductase activity; epoxide dehydrogenase activity; 3-ketoglucose-reductase activity; steroid dehydrogenase activity, acting on the CH-CH group of donors; 2-hydroxytetrahydrofuran dehydrogenase activity; S-(hydroxymethyl)glutathione dehydrogenase activity; 5-exo-hydroxycamphor dehydrogenase activity; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; xylose reductase activity
Biological Process: response to nitrosative stress; respiratory system process; ethanol catabolic process; formaldehyde catabolic process; peptidyl-cysteine S-nitrosylation; response to redox state; response to lipopolysaccharide; ethanol oxidation; retinoid metabolic process; positive regulation of blood pressure
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