Mouse CD79B Recombinant Protein – Cat# MBS959237

B-Cell Antigen Receptor Complex-Associated Protein Beta Chain (CD79B) Mouse Recombinant Protein

Name: CD79B Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS959237
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS959237

MBS959237 is a recombinant protein targeting Cd79b. Also known as Recombinant Mouse B-cell antigen receptor complex-associated protein beta chain (Cd79b). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

B-cell antigen receptor complex-associated protein beta chain (Cd79b), Recombinant Protein

Full Product Name

Recombinant Mouse B-cell antigen receptor complex-associated protein beta chain (Cd79b)

Product Gene Name

Cd79b recombinant protein

Product Synonym Gene Name

Cd79b; Igb

Product Synonym Names

B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD_antigen=; CD79b

Sequence

VPAMT SSDLPLNFQG SPCSQIWQHP RFAAKKRSSM VKFHCYTNHS GALTWFRKRG SQQPQELVSE EGRIVQTQNG SVYTLTIQNI QYEDNGIYFC KQKCDSANHN VTDSCGTELL VLGFSTLDQL KRRNTLKD

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

25,726 Da

Sequence Positions

26-158

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P15530

Species

Mus musculus (Mouse)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Cd79b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Cd79b. It may not necessarily be applicable to this product.

NCBI GI #

6680375

NCBI GeneID

15985

NCBI Accession #

NP_032365.1

UniProt Primary Accession #

P15530

UniProt Secondary Accession #

Q4FJP4

UniProt Related Accession #

P15530

GenBank Nucleotide #

NM_008339.2

NCBI Official Full Name

B-cell antigen receptor complex-associated protein beta chain

NCBI Official Synonym Full Names

CD79B antigen

NCBI Official Symbol

Cd79b

NCBI Official Synonym Symbols

B29; Igb; Igbeta; Ig-beta

UniProt Protein Name

B-cell antigen receptor complex-associated protein beta chain

UniProt Synonym Protein Names

B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD_antigen: CD79b

Protein Family

B-cell antigen receptor complex-associated protein

UniProt Gene Name

Cd79b

UniProt Synonym Gene Names

Igb

UniProt Entry Name

CD79B_MOUSE

NCBI Protein Information

B-cell antigen receptor complex-associated protein beta chain; immunoglobulin-associated beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein

UniProt Comments for Cd79b

Ig-beta: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: nucleoplasm; Golgi apparatus; membrane; cytoplasm; plasma membrane; integral to membrane; B cell receptor complex; external side of plasma membrane

Molecular Function: protein binding; transmembrane receptor activity

Biological Process: B cell receptor signaling pathway; cell surface receptor linked signal transduction; immune system process

Research Articles on Cd79b

1. Data indicate that in the absence of DGKzeta, the threshold for B cell antigen receptor (BCR) signaling, measured as activation of the Ras-extracellular signal-regulated kinase (ERK) pathway, was markedly reduced in mature follicular B cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Cd79b recombinant protein

Reference Product	PubMed Publications
Cd79a recombinant protein	>585 publications with Cd79b and Cd79a
Cd19 recombinant protein	>102 publications with Cd79b and Cd19
Lyn recombinant protein	>23 publications with Cd79b and Lyn
Blnk recombinant protein	>10 publications with Cd79b and Blnk
Btk recombinant protein	>9 publications with Cd79b and Btk
Blk recombinant protein	>4 publications with Cd79b and Blk
Vav1 recombinant protein	>3 publications with Cd79b and Vav1
Plcg2 recombinant protein	>1 publications with Cd79b and Plcg2

Pathways associated with Cd79b recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway antibodies	Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Signaling By The B Cell Receptor (BCR) Pathway antibodies	Signaling By The B Cell Receptor (BCR) Pathway Diagram

Diseases associated with Cd79b recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>360 publications with Cd79b and Neoplasms
Immune System Diseases Antibodies	>353 publications with Cd79b and Immune System Diseases
Lymphoma, Large B-Cell, Diffuse Antibodies	>71 publications with Cd79b and Lymphoma, Large B-Cell, Diffuse
Liver Diseases Antibodies	>16 publications with Cd79b and Liver Diseases
Hyperplasia Antibodies	>15 publications with Cd79b and Hyperplasia
Necrosis Antibodies	>10 publications with Cd79b and Necrosis
Liver Neoplasms Antibodies	>8 publications with Cd79b and Liver Neoplasms
Anemia Antibodies	>7 publications with Cd79b and Anemia
Fibrosis Antibodies	>5 publications with Cd79b and Fibrosis
Weight Loss Antibodies	>5 publications with Cd79b and Weight Loss

Organs/Tissues associated with Cd79b recombinant protein

Organ/Tissue Name	Pubmed Publications
Bone Marrow Antibodies	>108 publications with Cd79b and Bone Marrow
Lymph Node Antibodies	>87 publications with Cd79b and Lymph Node
Spleen Antibodies	>50 publications with Cd79b and Spleen
Liver Antibodies	>35 publications with Cd79b and Liver
Intestine Antibodies	>22 publications with Cd79b and Intestine
Lung Antibodies	>18 publications with Cd79b and Lung
Thymus Antibodies	>18 publications with Cd79b and Thymus
Salivary Gland Antibodies	>6 publications with Cd79b and Salivary Gland
Pancreas Antibodies	>6 publications with Cd79b and Pancreas