Macrosialin (CD68) Mouse Recombinant Protein

Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family.Holness C.L., da Silva R.P., Fawcett J., Gordon S., Simmons D.L.J. Biol. Chem. 268:9661-9666(1993) Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted protein.Jiang Z., Shih D.M., Xia Y.R., Lusis A.J., de Beer F.C., de Villiers W.J.S., van der Westhuyzen D.R., de Beer M.C.Genomics 50:199-205(1998) Functional comparison of the murine macrosialin and human CD68 promoters in macrophage and nonmacrophage cell lines.Greaves D.R., Quinn C.M., Seldin M.F., Gordon S.Genomics 54:165-168(1998) The macrosialin promoter directs high levels of transcriptional activity in macrophages dependent on combinatorial interactions between PU.1 and c-Jun.Li A.C., Guidez F.R.B., Collier J.G., Glass C.K.J. Biol. Chem. 273:5389-5399(1998) Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11.Miyashita A., Shimizu N., Endo N., Hanyuu T., Ishii N., Ito K., Itoh Y., Shirai M., Nakajima T., Odani S., Kuwano R.Gene 237:53-60(1999) Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice.Denny C.A., Kasperzyk J.L., Gorham K.N., Bronson R.T., Seyfried T.N.J. Neurosci. Res. 83:1028-1038(2006)

Small volumes of Cd68 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS960585 is a recombinant protein targeting Cd68. Also known as Recombinant Mouse Macrosialin. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.