DNA-Binding Protein Inhibitor Id-1 (ID1) Human Recombinant Protein

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ID1: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 20q11

Cellular Component: centrosome; Golgi apparatus; nucleoplasm; nucleus

Molecular Function: protein binding; protein C-terminus binding; protein homodimerization activity; protein N-terminus binding; transcription factor activity; transcription factor binding

Biological Process: angiogenesis; blood vessel endothelial cell migration; blood vessel morphogenesis; BMP signaling pathway; brain development; circadian rhythm; collagen metabolic process; endothelial cell morphogenesis; heart development; negative regulation of apoptosis; negative regulation of dendrite morphogenesis; negative regulation of endothelial cell differentiation; negative regulation of osteoblast differentiation; negative regulation of protein binding; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neuron differentiation; positive regulation of actin filament bundle formation; positive regulation of epithelial cell proliferation; protein destabilization; regulation of angiogenesis; regulation of MAPKKK cascade; response to antibiotic; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway