Midkine (MDK) Human Recombinant Protein

Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development.

A new family of heparin-binding factors strong conservation of midkine (MK) sequences between the human and the mouse.Tsutsui J., Uehara K., Kadomatsu K., Matsubara S., Muramatsu T.Biochem. Biophys. Res. Commun. 176:792-797(1991) Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins.Kretschmer P.J., Fairhurst J.L., Decker M.M., Chan C.P., Gluzman Y., Boehlen P., Kovesdi I.Growth Factors 5:99-114(1991) Genomic structure of human midkine (MK) , a retinoic acid-responsive growth/differentiation factor.Uehara K., Matsubara S., Kadomatsu K., Tsutsui J., Muramatsu T.J. Biochem. 111:563-567(1992) Structure of the gene coding for the human retinoic acid-inducible factor, MK.Fairhurst J.L., Kretschmer P.J., Gluzman Y., Boehlen P., Kovesdi I.DNA Cell Biol. 12:139-147(1993) Abnormal expression, highly efficient detection and novel truncations of midkine in human tumors, cancers and cell lines.Tao P., Xu D., Lin S., Ouyang G.L., Chang Y., Chen Q., Yuan Y., Zhuo X., Luo Q., Li J., Li B., Ruan L., Li Q., Li Z.Cancer Lett. 253:60-67(2007) Human chromosome 11 DNA sequence and analysis including novel gene identification.Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.Nature 440:497-500(2006) Amphiregulin-associated protein complete amino acid sequence of a protein produced by the 12-0-tetradecanoylphorbol-13-acetate-treated human breast adenocarcinoma cell line MCF-7.Shoyab M., McDonald V.L., Dick K., Modrell B., Malik N., Plowman G.D.Biochem. Biophys. Res. Commun. 179:572-578(1991) Identification of novel heparin-releasable proteins, as well as the cytokines midkine and pleiotrophin, in human postheparin plasma.Novotny W.F., Maffi T., Mehta R.L., Milner P.G.Arterioscler. Thromb. 13:1798-1805(1993) Signal peptide prediction based on analysis of experimentally verified cleavage sites.Zhang Z., Henzel W.J.Protein Sci. 13:2819-2824(2004) Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types.Stoica G.E., Kuo A., Powers C., Bowden E.T., Sale E.B., Riegel A.T., Wellstein A.J. Biol. Chem. 277:35990-35998(2002) Solution structure of midkine, a new heparin-binding growth factor.Iwasaki W., Nagata K., Hatanaka H., Inui T., Kimura T., Muramatsu T., Yoshida K., Tasumi M., Inagaki F.EMBO J. 16:6936-6946(1997)

Small volumes of MDK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS966767 is a recombinant protein targeting MDK. Also known as Recombinant Human Midkine. Host: E Coli.