RAD54 Like Protein 2 (RAD54L2) ELISA Kit for Camel

Function: Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54. Ref.1 Ref.2 Ref.7 Ref.8

Subunit structure: Interacts (via N-terminus) with spn-A/Rad51

By similarity.

Subcellular location: Nucleus Ref.2.

Developmental stage: Expressed both maternally and zygotically at all stages of fly development. Ref.1 Ref.2

Disruption phenotype: Eggs and embryos exhibit variable alterations along the dorsal-ventral and anterior-posterior axes. There is a reduction in the level of meiotic recombination and an increase in the frequency of non-disjunction. Larvae have increased sensitivity to ionizing radiation and MMS. Ref.1 Ref.2

Sequence similarities: Belongs to the SNF2/RAD54 helicase family.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain.

Sequence caution: The sequence AAL39744.2 differs from that shown. Reason: Erroneous initiation.