Human PPBP Active Protein – Cat# MBS969188

Platelet Basic Protein (PPBP) Human Active Protein

Name: PPBP Active Protein; Platelet Basic Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS969188
Price: 415 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS969188

$415 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Platelet basic protein (PPBP), Active Protein

Full Product Name

Recombinant Human Platelet basic protein (PPBP) (Active)

Product Gene Name

PPBP active protein

Product Synonym Gene Name

CTAP3; CXCL7; SCYB7; TGB1; THBGB1

Product Synonym Names

PBP; Leukocyte-derived growth factor; LDGF; Macrophage-derived growth factor; MDGF

Sequence

AELRCMCIKT TSGIHPKNIQ SLEVIGKGTH CNQVEVIATL KDGRKICLDP DAPRIKKIVQ KKLAGDESAD

Host

E Coli

Form/Format

Lyophilized

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.

Molecular Weight

7.6 kDa

Sequence Positions

59-128aa

OMIM

M54995 mRNA

3D Structure

ModBase 3D Structure for P02775

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Species

Homo sapiens (Human)

Biological Activity

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 1.0-10.0 ng/ml.

Endotoxin

Less than 1.0 EU/ug as determined by LAL method.

Protein Note

Protein will be provided with aseptic processing and endotoxin removal.

Product Categories/Family for PPBP active protein

Biological Active Protein; Immunology; Chemokine

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PPBP active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPBP purchase

MBS969188 is an active protein targeting PPBP. Also known as Recombinant Human Platelet basic protein (PPBP) (Active). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PPBP. It may not necessarily be applicable to this product.

NCBI GI #

4505981

NCBI GeneID

5473

NCBI Accession #

NP_002695.1

UniProt Primary Accession #

P02775

UniProt Secondary Accession #

Q6IBJ8; B2R5F3

UniProt Related Accession #

P02775; AAB46877

GenBank Nucleotide #

NM_002704.3

NCBI Official Full Name

platelet basic protein preproprotein

NCBI Official Synonym Full Names

pro-platelet basic protein

NCBI Official Symbol

PPBP

NCBI Official Synonym Symbols

PBP; TC1; TC2; TGB; LDGF; MDGF; TGB1; B-TG1; CTAP3; CXCL7; NAP-2; SCYB7; THBGB; LA-PF4; THBGB1; Beta-TG; CTAPIII; CTAP-III

UniProt Protein Name

Platelet basic protein

UniProt Synonym Protein Names

C-X-C motif chemokine 7; Leukocyte-derived growth factor; LDGF

Protein Family

Platelet basic protein

UniProt Gene Name

PPBP

UniProt Synonym Gene Names

CTAP3; CXCL7; SCYB7; TGB1; THBGB1; PBP; LDGF; MDGF; CTAP-III; CTAP-III(1-81); Beta-TG; NAP-2(74); NAP-2(73); NAP-2; NAP-2(1-66); NAP-2(1-63)

NCBI Protein Information

platelet basic protein

NCBI Summary for PPBP

The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]

UniProt Comments for PPBP

LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.

Research Articles on PPBP

1. Two haplotype blocks, one upstream to the coding region of UGT2A1 (rs146712414, P = 9.1 x 10(-5); odds ratio [OR], 1.34; 95% confidence interval [CI], 1.16-1.56) and one downstream of the genes PF4/PPBP/CXCL5 (rs1595009, P = 1.3 x 10(-4); OR, 1.32; 95% CI, 1.15-1.52), were associated with AgP.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PPBP active protein

Reference Product	PubMed Publications
CXCR2 active protein	>12 publications with PPBP and CXCR2
CCL5 active protein	>7 publications with PPBP and CCL5
CXCR1 active protein	>6 publications with PPBP and CXCR1
ALB active protein	>1 publications with PPBP and ALB
CXCL12 active protein	>1 publications with PPBP and CXCL12

Pathways associated with PPBP active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram

Diseases associated with PPBP active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>41 publications with PPBP and Inflammation
Cardiovascular Diseases Antibodies	>27 publications with PPBP and Cardiovascular Diseases
Heart Diseases Antibodies	>12 publications with PPBP and Heart Diseases
Lung Diseases Antibodies	>9 publications with PPBP and Lung Diseases
Atherosclerosis Antibodies	>7 publications with PPBP and Atherosclerosis
Necrosis Antibodies	>6 publications with PPBP and Necrosis
Carcinoma Antibodies	>3 publications with PPBP and Carcinoma
Edema Antibodies	>3 publications with PPBP and Edema
Hypersensitivity Antibodies	>3 publications with PPBP and Hypersensitivity
Breast Neoplasms Antibodies	>2 publications with PPBP and Breast Neoplasms

Organs/Tissues associated with PPBP active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>121 publications with PPBP and Blood
Connective Tissue Antibodies	>77 publications with PPBP and Connective Tissue
Lung Antibodies	>9 publications with PPBP and Lung
Heart Antibodies	>5 publications with PPBP and Heart
Bone Marrow Antibodies	>5 publications with PPBP and Bone Marrow
Prostate Antibodies	>3 publications with PPBP and Prostate
Intestine Antibodies	>3 publications with PPBP and Intestine
Liver Antibodies	>3 publications with PPBP and Liver