Mouse IL1RN Active Protein – Cat# MBS969445

Interleukin-1 Receptor Antagonist Protein (IL1RN) Mouse Active Protein

Name: IL1RN Active Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS969445
Price: 560 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS969445

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. More details

$560 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin-1 receptor antagonist protein (Il1rn), Active Protein

Full Product Name

Recombinant Mouse Interleukin-1 receptor antagonist protein (Il1rn) (Active)

Product Gene Name

Il1rn active protein

Product Synonym Gene Name

Il-1ra

Product Synonym Names

IL-1RN; IRAP; IL1 inhibitor

Sequence

RPSGKRPCKM QAFRIWDTNQ KTFYLRNNQL IAGYLQGPNI KLEEKIDMVP IDLHSVFLGI HGGKLCLSCA KSGDDIKLQL EEVNITDLSK NKEEDKRFTF IRSEKGPTTS FESAACPGWF LCTTLEADRP VSLTNTPEEP LIVTKFYFQE DQ

Host

E Coli

Form/Format

Lyophilized

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.

Molecular Weight

17.3 kDa

Sequence Positions

27-178aa

3D Structure

ModBase 3D Structure for P25085

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Species

Mus musculus (Mouse)

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1alpha- dependent proliferation of murine D10S cells is less than 50 ng/ml, corresponding to a specific activity of > 2.0 × 104 IU/mg in the presence of 50 pg/ml rHuIL-1alpha.

Endotoxin

Less than 1.0 EU/ug as determined by LAL method.

Protein Note

Protein will be provided with aseptic processing and endotoxin removal.

Product Categories/Family for Il1rn active protein

Biological Active Protein; Immunology; Interleukin

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Il1rn active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Il1rn purchase

MBS969445 is an active protein targeting Il1rn. Also known as Recombinant Mouse Interleukin-1 receptor antagonist protein (Il1rn) (Active). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Il1rn. It may not necessarily be applicable to this product.

NCBI GI #

89257344

NCBI GeneID

16181

NCBI Accession #

NP_001034790.1

UniProt Primary Accession #

P25085

UniProt Secondary Accession #

O70207

UniProt Related Accession #

P25085

GenBank Nucleotide #

NM_001039701.3

NCBI Official Full Name

interleukin-1 receptor antagonist protein isoform 2

NCBI Official Synonym Full Names

interleukin 1 receptor antagonist

NCBI Official Symbol

Il1rn

NCBI Official Synonym Symbols

IL-1ra; F630041P17Rik

UniProt Protein Name

Interleukin-1 receptor antagonist protein

UniProt Synonym Protein Names

IL1 inhibitor

Protein Family

Interleukin-1 receptor antagonist protein

UniProt Gene Name

Il1rn

UniProt Synonym Gene Names

Il-1ra; IL-1RN; IL-1ra; IRAP

NCBI Protein Information

interleukin-1 receptor antagonist protein

UniProt Comments for Il1rn

IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted; Secreted, signal peptide; Vesicle

Chromosomal Location of Human Ortholog: 2 A3|2 16.36 cM

Cellular Component: extracellular region; extracellular space; vesicle

Molecular Function: cytokine activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type I receptor antagonist activity; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type I receptor binding; interleukin-1, Type II receptor binding

Biological Process: acute-phase response; cytokine and chemokine mediated signaling pathway; fever; insulin secretion; lipid metabolic process; memory; negative regulation of apoptosis; negative regulation of cell migration; negative regulation of glutamate secretion; negative regulation of heterotypic cell-cell adhesion; negative regulation of membrane potential; positive regulation of JNK activity; response to glucocorticoid stimulus; sensory perception of pain

Research Articles on Il1rn

1. The current study is the first to demonstrate ex vivo airway hyperreactivity caused by systemic maternal inflammation and postnatal hyperoxia, and it reveals further preclinical mechanistic insights into IL-1Ra as a treatment targeting key pathophysiological features of Bronchopulmonary dysplasia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Il1rn active protein

Reference Product	PubMed Publications
Il1b active protein	>221 publications with Il1rn and Il1b
Il1a active protein	>104 publications with Il1rn and Il1a
Il1r1 active protein	>19 publications with Il1rn and Il1r1
Il1r2 active protein	>7 publications with Il1rn and Il1r2
Lcn2 active protein	>3 publications with Il1rn and Lcn2
Myd88 active protein	>3 publications with Il1rn and Myd88
Irak3 active protein	>1 publications with Il1rn and Irak3

Pathways associated with Il1rn active protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
IL-1 Signaling Pathway antibodies	IL-1 Signaling Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Interleukin-1 Signaling Pathway antibodies	Interleukin-1 Signaling Pathway Diagram
Signaling By Interleukins Pathway antibodies	Signaling By Interleukins Pathway Diagram

Diseases associated with Il1rn active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>785 publications with Il1rn and Necrosis
Inflammation Antibodies	>722 publications with Il1rn and Inflammation
Arthritis, Rheumatoid Antibodies	>305 publications with Il1rn and Arthritis, Rheumatoid
Disease Models, Animal Antibodies	>168 publications with Il1rn and Disease Models, Animal
Skin Diseases Antibodies	>130 publications with Il1rn and Skin Diseases
Pain Antibodies	>84 publications with Il1rn and Pain
Kidney Diseases Antibodies	>81 publications with Il1rn and Kidney Diseases
Heart Diseases Antibodies	>77 publications with Il1rn and Heart Diseases
Liver Diseases Antibodies	>61 publications with Il1rn and Liver Diseases
Fibrosis Antibodies	>53 publications with Il1rn and Fibrosis

Organs/Tissues associated with Il1rn active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1087 publications with Il1rn and Blood
Skin Antibodies	>129 publications with Il1rn and Skin
Bone Marrow Antibodies	>68 publications with Il1rn and Bone Marrow
Stomach Antibodies	>52 publications with Il1rn and Stomach
Connective Tissue Antibodies	>50 publications with Il1rn and Connective Tissue
Spleen Antibodies	>44 publications with Il1rn and Spleen
Intestine Antibodies	>40 publications with Il1rn and Intestine
Eye Antibodies	>39 publications with Il1rn and Eye
Vagina Antibodies	>11 publications with Il1rn and Vagina
Thymus Antibodies	>7 publications with Il1rn and Thymus