Exportin 1 (XPO1) ELISA Kit for Pigeon

Function: Receptor for the leucine-rich nuclear export signal (NES). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form. Required for the function or maintenance of certain tissues such as brain and gut. Involved in the export of dl from the nucleus to the cytoplasm. Ref.1 Ref.2 Ref.7

Subunit structure: Interacts with Clbn (via its N-terminus)

By similarity. Interacts with mbo to form components of the nuclear pore complex, of which Nup214 is also a member. Interacts with target proteins containing NES sequences such as actin and dl. Ref.1 Ref.7

Subcellular location: Nucleus › nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side Ref.2 Ref.7.

Tissue specificity: High expression observed in the developing embryonic brain, hind gut and posterior spiracles shortly before dorsal closure; and in the ventral nerve cord, midgut and somatic musculature shortly after dorsal closure. Expression increases when the tissue is well developed. Ref.1

Developmental stage: Highly expressed both maternally and zygotically. Ref.1

Miscellaneous: Activity inhibited by leptomycin B, which disrupts interaction with the NES and RanGTP. Ref.2

Sequence similarities: Belongs to the exportin family.Contains 1 importin N-terminal domain.