Mouse BMP-2 Active Protein – Cat# MBS9718733

Fig.SDS-PAGE analysis of Mouse BMP-2 protein.

BMP-2 Mouse Active Protein

Name: BMP-2 Active Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS9718733
Price: 485 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9718733

BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

BMP-2, Active Protein

Full Product Name

Mouse BMP-2 Protein

Product Gene Name

BMP-2 active protein

Product Synonym Names

Recombinant Mouse BMP-2 Protein (Bone morphogenetic protein 2) expressed in E. coli; BDA2; BDA2A; BMP-2; BMP2A; Bone morphogenetic protein 2; BMP2

Sequence

Amino acid sequence derived from mature form of human BMP2 (NP_001191 .1) (Gln283-Ar g396) was expressed. The mature form sequences of human, mouse, rat, rhesus and canine BMP2 are identical.

Host

E Coli

Form/Format

Lyophilized from sterile 30 % CAN, 0.1 % TFA, pH 2.9.

Purity/Purification

>95% as determined by SDS-PAGE

Preparation and Storage

Item should be stored desiccated below -20 degree C. Upon reconstitution, the protein should be stored at 4 degree C between 2-7 days and for future use below -20 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Molecular Weight

13 kDa

3D Structure

ModBase 3D Structure for P12643

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Species

Mouse

Protein Length

The recombinant human BMP2 monomer consists of 115 amino acids and has a predicted molecular mass of 13 kDa.

Activity

Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.5-2 mug/ml.

Usage Notes

Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Mouse BMP-2 protein in sterile ddH2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

Other Notes

Small volumes of BMP-2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMP-2 purchase

MBS9718733 is an active protein targeting BMP-2. Also known as Mouse BMP-2 Protein. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP-2. It may not necessarily be applicable to this product.

NCBI GI #

4557369

NCBI GeneID

650

NCBI Accession #

NP_001191.1

UniProt Primary Accession #

P12643

UniProt Related Accession #

P12643

GenBank Nucleotide #

NP_001191.1

NCBI Official Full Name

bone morphogenetic protein 2 preproprotein

NCBI Official Synonym Full Names

bone morphogenetic protein 2

NCBI Official Symbol

BMP2

NCBI Official Synonym Symbols

BDA2; BMP2A; SSFSC

Protein Family

BMP-2-inducible protein kinase

NCBI Protein Information

bone morphogenetic protein 2

NCBI Summary for BMP-2

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]

Research Articles on BMP-2

1. BMP2 mutation c.393A>T (p. Arg131Ser) affects bone morphogenetic protein signaling activity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with BMP-2 active protein

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
BMP Signaling Pathway antibodies	BMP Signaling Pathway Diagram
BMP Signaling Pathway antibodies	BMP Signaling Pathway Diagram
BMP2-WNT4-FOXO1 Pathway In Human Primary Endometrial Stromal Cell Differentiation antibodies	BMP2-WNT4-FOXO1 Pathway In Human Primary Endometrial Stromal Cell Differentiation Diagram
Basal Cell Carcinoma Pathway antibodies	Basal Cell Carcinoma Pathway Diagram
Basal Cell Carcinoma Pathway antibodies	Basal Cell Carcinoma Pathway Diagram
Bone Morphogenic Protein (BMP) Signalling And Regulation Pathway antibodies	Bone Morphogenic Protein (BMP) Signalling And Regulation Pathway Diagram
Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway antibodies	Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram