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BMP6 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS539568

MBS539568 is an active protein targeting BMP6. Also known as BMP6 protein. Host: Human. Purified recombinant Human BMP6 protein More details

$685 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BMP6, Active Protein
Full Product Name
BMP6 protein
Product Gene Name
BMP6 active protein
Product Synonym Names
BMP 6 protein; VGR protein; BMP6; Bone Morphogenetic protein 6 protein; BMP-6; BMP-6 protein; BMP 6
Sequence
Region of BMP6 protein correspond ing to amino acids VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH.
Host
Human
Form/Format
Lyophilized from 10mM Tris, pH 9.0. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
Purity/Purification
> 95% pure
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
26.2 kDa
OMIM
112266
3D Structure
ModBase 3D Structure for P22004
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Protein Type
Recombinant
Bioactivity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 ug/ml.
Endotoxin Levels
Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Expression System
HEK cells

Product Categories/Family for BMP6 active protein

Differentiation & Development
Applications Tested/Suitable for BMP6 active protein
User optimized

Other Notes

Small volumes of BMP6 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP6. It may not necessarily be applicable to this product.

NCBI GI #
3492993
NCBI GeneID
654
NCBI Accession #
AAC33283.1
UniProt Primary Accession #
P22004
UniProt Secondary Accession #
Q5TCP3
UniProt Related Accession #
P22004
NCBI Official Full Name
bone morphogenetic protein 6, partial
NCBI Official Synonym Full Names
bone morphogenetic protein 6
NCBI Official Symbol
BMP6
NCBI Official Synonym Symbols
VGR; VGR1
UniProt Protein Name
Bone morphogenetic protein 6
UniProt Synonym Protein Names
VG-1-related protein; VG-1-R; VGR-1
Protein Family
Bone morphogenetic protein
UniProt Gene Name
BMP6
UniProt Synonym Gene Names
VGR; BMP-6; VG-1-R; VGR-1
UniProt Entry Name
BMP6_HUMAN
NCBI Protein Information
bone morphogenetic protein 6

NCBI Summary for BMP6

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]
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UniProt Comments for BMP6

BMP6: Induces cartilage and bone formation. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p24-p23

Cellular Component: extracellular space; cytoplasm

Molecular Function: growth factor activity; protein heterodimerization activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: cellular iron ion homeostasis; response to glucocorticoid stimulus; BMP signaling pathway; regulation of apoptosis; response to magnesium ion; positive regulation of endothelial cell differentiation; positive regulation of aldosterone biosynthetic process; male genitalia development; kidney development; inflammatory response; response to iron ion; skeletal development; endochondral ossification; response to retinoic acid; positive regulation of bone mineralization; osteoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of chondrocyte differentiation; eye development; positive regulation of protein secretion; regulation of MAPKKK cascade; cartilage development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; immune response; response to activity; positive regulation of neuron differentiation; positive regulation of epithelial cell proliferation; growth
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Research Articles on BMP6

1. CpG island methylation of BMP6 is found in high frequency in CRC and this epigenetic event is associated with suppressed protein expression in the tumor tissue.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BMP6 active protein

 Reference Product  PubMed Publications
 BMPR2 active protein  >59 publications with BMP6 and BMPR2
 SMAD1 active protein  >56 publications with BMP6 and SMAD1
 SMAD5 active protein  >27 publications with BMP6 and SMAD5
 BMPR1A active protein  >18 publications with BMP6 and BMPR1A
 BMPR1B active protein  >17 publications with BMP6 and BMPR1B
 SMAD7 active protein  >11 publications with BMP6 and SMAD7
 ACVR2A active protein  >4 publications with BMP6 and ACVR2A
 NOG active protein  >2 publications with BMP6 and NOG

Pathways associated with BMP6 active protein

 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram

Diseases associated with BMP6 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >33 publications with BMP6 and Inflammation
 Disease Models, Animal Antibodies  >29 publications with BMP6 and Disease Models, Animal
 Hemochromatosis Antibodies  >28 publications with BMP6 and Hemochromatosis
 Liver Diseases Antibodies  >20 publications with BMP6 and Liver Diseases
 Adenocarcinoma Antibodies  >18 publications with BMP6 and Adenocarcinoma
 Fibrosis Antibodies  >14 publications with BMP6 and Fibrosis
 Kidney Diseases Antibodies  >12 publications with BMP6 and Kidney Diseases
 Nervous System Diseases Antibodies  >12 publications with BMP6 and Nervous System Diseases
 Necrosis Antibodies  >12 publications with BMP6 and Necrosis
 Lung Diseases Antibodies  >8 publications with BMP6 and Lung Diseases

Organs/Tissues associated with BMP6 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >92 publications with BMP6 and Blood
 Connective Tissue Antibodies  >47 publications with BMP6 and Connective Tissue
 Ovary Antibodies  >39 publications with BMP6 and Ovary
 Brain Antibodies  >33 publications with BMP6 and Brain
 Embryonic Tissue Antibodies  >33 publications with BMP6 and Embryonic Tissue
 Vascular Antibodies  >27 publications with BMP6 and Vascular
 Prostate Antibodies  >25 publications with BMP6 and Prostate
 Kidney Antibodies  >20 publications with BMP6 and Kidney
 Mouth Antibodies  >17 publications with BMP6 and Mouth
 Lung Antibodies  >12 publications with BMP6 and Lung
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