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CAT Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204136

CAT is a key antioxidant enzyme in the bodies defense against oxidative stress. Also, it is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. CAT converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby… More details

$230 / 0.02 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CAT, Active Protein
Full Product Name
CAT, 1-527aa, Human, His tag, E Coli (Bioactivity Validated)
Product Gene Name
CAT active protein
Product Synonym Names
Catalase
Sequence
MGSSHHHHHH SSGLVPRGSH MADSRDPASD QMQHWKEQRA AQKADVLTTG AGNPVGDKLN VITVGPRGPL LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITKYSKAKVF EHIGKKTPIA VRFSTVAGES GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDPIL FPSFIHSQKR NPQTHLKDPD MVWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNANGEAV YCKFHYKTDQ GIKNLSVEDA ARLSQEDPDY GIRDLFNAIA TGKYPSWTFY IQVMTFNQAE TFPFNPFDLT KVWPHKDYPL IPVGKLVLNR NPVNYFAEVE QIAFDPSNMP PGIEASPDKM LQGRLFAYPD THRHRLGPNY LHIPVNCPYR ARVANYQRDG PMCMQDNQGG APNYYPNSFG APEQQPSALE HSIQYSGEVR RFNTANDDNV TQVRAFYVNV LNEEQRKRLC ENIAGHLKDA QIFIQKKAVK NFTEVHPDYG SHIQALLDKY NAEKPKNAIH TFVQSGSHLA AREKANL
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol
Purity/Purification
> 90% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
61.9 kDa (547aa)
3D Structure
ModBase 3D Structure for P04040
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Antigen Species
Human
Tag Information
His-tag
Biological Activity
Specific activity is > 70,000 units/mg. One unit will decompose 1.0umole of H2O2 per minute at pH 8.0 at 25C.

Product Categories/Family for CAT active protein

Metabolism
Applications Tested/Suitable for CAT active protein
SDS-PAGE

SDS-Page of CAT active protein

CAT Active Protein – Cat# MBS204136

Product References and Citations for CAT active protein

Freitas MO, et al. (2011) J Biol Chem. 2011 Nov 25;286 (47):40509-19. Epub 2011 Oct 5.

Other Notes

Small volumes of CAT active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAT purchase

MBS204136 is an active protein targeting CAT. Also known as CAT, 1-527aa, Human, His tag, E Coli (Bioactivity Validated). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CAT. It may not necessarily be applicable to this product.

NCBI GI #
4557014
NCBI GeneID
847
NCBI Accession #
NP_001743
UniProt Primary Accession #
P04040
UniProt Secondary Accession #
Q2M1U4; Q4VXX5; Q9BWT9; Q9UC85; A8K6C0; B2RCZ9; D3DR07
UniProt Related Accession #
P04040
GenBank Nucleotide #
NM_001752.3
NCBI Official Full Name
catalase
NCBI Official Synonym Full Names
catalase
NCBI Official Symbol
CAT
UniProt Protein Name
Catalase
Protein Family
Cat eye syndrome critical region protein
UniProt Gene Name
CAT
NCBI Protein Information
catalase

NCBI Summary for CAT

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
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UniProt Comments for CAT

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.

Research Articles on CAT

1. Gene expression microarrays in A375 melanoma cells with different ROS levels after overexpressing catalase were performed. Gene expression signature could be relevant in clinical prognostic to classify between non aggressive and metastatic melanomas.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CAT active protein

 Reference Product  PubMed Publications
 SOD1 active protein  >369 publications with CAT and SOD1
 SOD2 active protein  >287 publications with CAT and SOD2
 GSR active protein  >69 publications with CAT and GSR
 SOD3 active protein  >38 publications with CAT and SOD3
 AKT1 active protein  >21 publications with CAT and AKT1
 PRDX1 active protein  >20 publications with CAT and PRDX1
 ALDH2 active protein  >7 publications with CAT and ALDH2

Pathways associated with CAT active protein

 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 FoxO Family Signaling Pathway antibodies  FoxO Family Signaling Pathway Diagram

Diseases associated with CAT active protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1785 publications with CAT and Necrosis
 Diabetes Mellitus Antibodies  >1596 publications with CAT and Diabetes Mellitus
 Asthma Antibodies  >1524 publications with CAT and Asthma
 Hypertension Antibodies  >1047 publications with CAT and Hypertension
 Disease Progression Antibodies  >886 publications with CAT and Disease Progression
 Edema Antibodies  >856 publications with CAT and Edema
 Seizures Antibodies  >792 publications with CAT and Seizures
 Heart Failure Antibodies  >681 publications with CAT and Heart Failure
 Brain Ischemia Antibodies  >640 publications with CAT and Brain Ischemia
 Reperfusion Injury Antibodies  >566 publications with CAT and Reperfusion Injury

Organs/Tissues associated with CAT active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >24501 publications with CAT and Brain
 Blood Antibodies  >19270 publications with CAT and Blood
 Nerve Antibodies  >10668 publications with CAT and Nerve
 Muscle Antibodies  >10330 publications with CAT and Muscle
 Eye Antibodies  >6124 publications with CAT and Eye
 Liver Antibodies  >6065 publications with CAT and Liver
 Heart Antibodies  >5641 publications with CAT and Heart
 Vascular Antibodies  >5487 publications with CAT and Vascular
 Skin Antibodies  >4823 publications with CAT and Skin
 Kidney Antibodies  >4049 publications with CAT and Kidney
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