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CD26/DPP4 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206844

DPP4, dipeptidyl peptidase-4 is a complex enzyme expressed on the surface of most cell types and is a serine exopeptidase that cleaves x-proline dipeptides from the N-terminus of polypeptides. DPP4 protein is associated with intracellular signal transduction,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD26/DPP4, Active Protein
Full Product Name
Recombinant human CD26/DPP4 protein
Product Gene Name
CD26/DPP4 active protein
Product Synonym Names
Dipeptidyl peptidase 4; dipeptidyl peptidase 4 isoform 1; ADABP; ADCP2; CD26; DPPIV; TP103; Adenosine deaminase complexing protein 2; Dipeptidyl peptidase IV; DPP4; T-cell activation antigen CD26
Sequence
Asp
NKGTDD ATADSRKTYT LTDYLKNTYR LKLYSLRWIS DHEYLYKQEN NILVFNAEYG NSSVFLENST FDEFGHSIND YSISPDGQFI LLEYNYVKQW RHSYTASYDI YDLNKRQLIT EERIPNNTQW VTWSPVGHKL AYVWNNDIYV KIEPNLPSYR ITWTGKEDII YNGITDWVYE EEVFSAYSAL WWSPNGTFLA YAQFNDTEVP LIEYSFYSDE SLQYPKTVRV PYPKAGAVNP TVKFFVVNTD SLSSVTNATS IQITAPASML IGDHYLCDVT WATQERISLQ WLRRIQNYSV MDICDYDESS GRWNCLVARQ HIEMSTTGWV GRFRPSEPHF TLDGNSFYKI ISNEEGYRHI CYFQIDKKDC TFITKGTWEV IGIEALTSDY LYYISNEYKG MPGGRNLYKI QLSDYTKVTC LSCELNPERC QYYSVSFSKE AKYYQLRCSG PGLPLYTLHS SVNDKGLRVL EDNSALDKML QNVQMPSKKL DFIILNETKF WYQMILPPHF DKSKKYPLLL DVYAGPCSQK ADTVFRLNWA TYLASTENII VASFDGRGSG YQGDKIMHAI NRRLGTFEVE DQIEAARQFS KMGFVDNKRI AIWGWSYGGY VTSMVLGSGS GVFKCGIAVA PVSRWEYYDS VYTERYMGLP TPEDNLDHYR NSTVMSRAEN FKQVEYLLIH GTADDNVHFQ QSAQISKALV DVGVDFQAMW YTDEDHGIAS STAHQHIYTH MSHFIKQCFS LP
Host
HEK293
Form/Format
Liquid in. Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
Purity/Purification
> 95% by SDS-PAGE
Concentration
0.25mg/ml (determined by Absorbance at 280nm) (lot specific)
Preparation and Storage
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
766
Sequence Positions
29-766aa
Chromosome Location
Chromosome: 2; NC_000002.11 (162848751..162931052, complement). Location: 2q24.3
OMIM
102720
3D Structure
ModBase 3D Structure for P27487
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Tag
hIgG-Tag

Product Categories/Family for CD26/DPP4 active protein

Angiogenesis, Cardiovascular, Adhesion & Movement; Proteins
Applications Tested/Suitable for CD26/DPP4 active protein
SDS-PAGE (SDS), Enzyme Activity, Bioactivity

SDS-PAGE of CD26/DPP4 active protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain
CD26/DPP4 Active Protein – Cat# MBS206844

Activity of CD26/DPP4 active protein

MERS-CoV Spike S1 Subunit is coated at 2 ug/ml (100 ul/well) can bind IgK-DPP4. The ED50 range <=250 ng/ml.
CD26/DPP4 Active Protein, Activity – Cat# MBS206844

Activity of CD26/DPP4 active protein

MERS-CoV Spike RBD is coated at 2 ug/ml (100 ul/well) can bind IgK-DPP4. The ED50 range <=200 ng/ml.
CD26/DPP4 Active Protein, Activity – Cat# MBS206844

Activity of CD26/DPP4 active protein

MERS-CoV Spike is coated at 2 ug/ml (100 ul/well) can bind IgK-DPP4. The ED50 range <=120 ng/ml.
CD26/DPP4 Active Protein, Activity – Cat# MBS206844

Product References and Citations for CD26/DPP4 active protein

Pratley RE and Salsali A. (2007) Curr Med Res Opin. 23(4):919-31.
Rosenstock J. and Zinman B. (2007) Curr Opin Endocrino Diabetes Obes.60(11):1454-70.
Barnett A. (2006). J.Clin. Pract. 60(11):1454-70.

Other Notes

Small volumes of CD26/DPP4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD26/DPP4 purchase

MBS206844 is an active protein targeting CD26/DPP4. Also known as Recombinant human CD26/DPP4 protein. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for CD26/DPP4. It may not necessarily be applicable to this product.

NCBI GI #
18765694
NCBI GeneID
1803
NCBI Accession #
NP_001926.2
UniProt Primary Accession #
P27487
UniProt Secondary Accession #
Q53TN1
UniProt Related Accession #
P27487
GenBank Nucleotide #
NM_001935.3
NCBI Official Full Name
dipeptidyl peptidase 4
NCBI Official Synonym Full Names
dipeptidyl-peptidase 4
NCBI Official Symbol
DPP4
NCBI Official Synonym Symbols
CD26; ADABP; ADCP2; DPPIV; TP103
UniProt Protein Name
Dipeptidyl peptidase 4
UniProt Synonym Protein Names
ADABP; Adenosine deaminase complexing protein 2; ADCP-2; Dipeptidyl peptidase IV; DPP IV; T-cell activation antigen CD26; TP103; CD_antigen: CD26Cleaved into the following 2 chains:Dipeptidyl peptidase 4 membrane formAlternative name(s):Dipeptidyl peptidase IV membrane form
UniProt Gene Name
DPP4
UniProt Synonym Gene Names
ADCP2; CD26; ADCP-2; DPP IV
UniProt Entry Name
DPP4_HUMAN
NCBI Protein Information
dipeptidyl peptidase 4; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD26/DPP4 active protein

 Reference Product  PubMed Publications
 GIP active protein  >48 publications with CD26/DPP4 and GIP
 ADA active protein  >19 publications with CD26/DPP4 and ADA
 CXCL12 active protein  >18 publications with CD26/DPP4 and CXCL12
 CXCL10 active protein  >4 publications with CD26/DPP4 and CXCL10
 CCL5 active protein  >2 publications with CD26/DPP4 and CCL5
 GCG active protein  >2 publications with CD26/DPP4 and GCG
 CXCL11 active protein  >1 publications with CD26/DPP4 and CXCL11
 CXCL9 active protein  >1 publications with CD26/DPP4 and CXCL9
 CCL11 active protein  >1 publications with CD26/DPP4 and CCL11

Pathways associated with CD26/DPP4 active protein

 Products by Pathway  Pathway Diagram
 Incretin Synthesis, Secretion, And Inactivation Pathway antibodies  Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway antibodies  Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway Diagram
 Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway antibodies  Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway Diagram

Diseases associated with CD26/DPP4 active protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >65 publications with CD26/DPP4 and Neoplasms
 Cardiovascular Diseases Antibodies  >49 publications with CD26/DPP4 and Cardiovascular Diseases
 Inflammation Antibodies  >36 publications with CD26/DPP4 and Inflammation
 Disease Models, Animal Antibodies  >36 publications with CD26/DPP4 and Disease Models, Animal
 Weight Loss Antibodies  >31 publications with CD26/DPP4 and Weight Loss
 Liver Diseases Antibodies  >17 publications with CD26/DPP4 and Liver Diseases
 Adenocarcinoma Antibodies  >14 publications with CD26/DPP4 and Adenocarcinoma
 Necrosis Antibodies  >13 publications with CD26/DPP4 and Necrosis
 Kidney Diseases Antibodies  >12 publications with CD26/DPP4 and Kidney Diseases
 Drug Toxicity Antibodies  >12 publications with CD26/DPP4 and Drug Toxicity

Organs/Tissues associated with CD26/DPP4 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >256 publications with CD26/DPP4 and Blood
 Pancreas Antibodies  >66 publications with CD26/DPP4 and Pancreas
 Liver Antibodies  >40 publications with CD26/DPP4 and Liver
 Vascular Antibodies  >33 publications with CD26/DPP4 and Vascular
 Heart Antibodies  >33 publications with CD26/DPP4 and Heart
 Kidney Antibodies  >32 publications with CD26/DPP4 and Kidney
 Intestine Antibodies  >24 publications with CD26/DPP4 and Intestine
 Muscle Antibodies  >21 publications with CD26/DPP4 and Muscle
 Skin Antibodies  >20 publications with CD26/DPP4 and Skin
 Brain Antibodies  >18 publications with CD26/DPP4 and Brain
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