Human CXCL10 Active Protein – Cat# MBS9719490

CXCL10 Human Active Protein

Name: CXCL10 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS9719490
Price: 150 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9719490

C-X-C motif chemokine 10 (CXCL10) also named Interferon gamma-induced protein 10 (IP-10), which is a chemokine of the intercrine alpha family. CXCL10 is a 8.55kDa protein containing 77 amino acid residues. CXCL10 is produced by the several cell types like… More details

$150 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CXCL10, Active Protein

Full Product Name

Human CXCL10 Protein, His tag (Animal-Free)

Product Gene Name

CXCL10 active protein

Product Synonym Names

IP-10; Gamma-Interferon Inducible Protein 10; Crg-2

Sequence

VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSPwit hpolyhisti dinetagatt heN-termin us.

Host

E coli

Form/Format

The protein was lyophilized from a 0.2 um filtered solution containing 1X PBS, pH 7.4. If you have any concerns or special requirements, please confirm with us.

Purity/Purification

>98% as determined by SDS-PAGE

Preparation and Storage

Lyophilized protein should be stored at -20 degree C for 1 year. Upon reconstitution, store at 2 degree C to 8 degree C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10%FBS, 5%HSA or 5% trehalose solution), protein aliquots should be stored at -20 degree C or -80 degree C for 3-6 months. Avoid repeated freeze/thaw cycles.

Molecular Weight

10,881 Da

OMIM

147310

3D Structure

ModBase 3D Structure for P02778

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin

<0.1 EU per 1 ug of the protein by the LAL method.

Activity

Measured by its ability to chemoattract human PBMCs using a concentration range of 10.0 - 100.0 ng/mL. Note: Results may vary from different PBMC donors.

Usage Notes

Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human CXCL10 Protein, His tag (Animal-Free) using the buffer we provided not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Product Categories/Family for CXCL10 active protein

Cytokines and proteins; Cytology; Cell Research Tools; Cell Culture

Other Notes

Small volumes of CXCL10 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCL10 purchase

MBS9719490 is an active protein targeting CXCL10. Also known as Human CXCL10 Protein, His tag (Animal-Free). Host: E coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL10. It may not necessarily be applicable to this product.

NCBI GI #

149999382

NCBI GeneID

3627

NCBI Accession #

NP_001556.2

UniProt Primary Accession #

P02778

UniProt Secondary Accession #

Q96QJ5

UniProt Related Accession #

P02778

GenBank Nucleotide #

NM_001565.3

NCBI Official Full Name

C-X-C motif chemokine 10

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 10

NCBI Official Symbol

CXCL10

NCBI Official Synonym Symbols

C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10

UniProt Protein Name

C-X-C motif chemokine 10

UniProt Synonym Protein Names

10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Small-inducible cytokine B10

Protein Family

C-X-C motif chemokine

UniProt Gene Name

CXCL10

UniProt Synonym Gene Names

INP10; SCYB10; Gamma-IP10; IP-10

UniProt Entry Name

CXL10_HUMAN

NCBI Protein Information

C-X-C motif chemokine 10; gamma IP10; gamma-IP10; small-inducible cytokine B10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X

NCBI Summary for CXCL10

This gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Jul 2008]

UniProt Comments for CXCL10

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Chemokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity; cAMP-dependent protein kinase regulator activity; receptor binding

Biological Process: muscle development; blood circulation; protein secretion; positive regulation of leukocyte chemotaxis; positive regulation of cAMP metabolic process; chemotaxis; signal transduction; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cell surface receptor linked signal transduction; response to vitamin D; cell-cell signaling; positive regulation of cell proliferation; response to gamma radiation; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of release of sequestered calcium ion into cytosol; response to cold; inflammatory response; negative regulation of myoblast differentiation; regulation of protein kinase activity; defense response to virus

Research Articles on CXCL10

1. Increased CXCL9 serum levels in hepatitis C-related mixed cryoglobulinemia, with autoimmune thyroiditis, associated with high levels of CXCL10.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CXCL10 active protein

Reference Product	PubMed Publications
CXCL9 active protein	>871 publications with CXCL10 and CXCL9
CXCR3 active protein	>795 publications with CXCL10 and CXCR3
CCL5 active protein	>614 publications with CXCL10 and CCL5
CXCL11 active protein	>440 publications with CXCL10 and CXCL11
CCR5 active protein	>167 publications with CXCL10 and CCR5
CCL20 active protein	>103 publications with CXCL10 and CCL20
CCL11 active protein	>97 publications with CXCL10 and CCL11
CXCR2 active protein	>48 publications with CXCL10 and CXCR2
CCR3 active protein	>47 publications with CXCL10 and CCR3
CCR1 active protein	>46 publications with CXCL10 and CCR1

Pathways associated with CXCL10 active protein

Products by Pathway	Pathway Diagram
CXCR3-mediated Signaling Events Pathway antibodies	CXCR3-mediated Signaling Events Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with CXCL10 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>1078 publications with CXCL10 and Inflammation
Necrosis Antibodies	>635 publications with CXCL10 and Necrosis
Neoplasms Antibodies	>429 publications with CXCL10 and Neoplasms
Lung Diseases Antibodies	>308 publications with CXCL10 and Lung Diseases
Liver Diseases Antibodies	>203 publications with CXCL10 and Liver Diseases
Cardiovascular Diseases Antibodies	>158 publications with CXCL10 and Cardiovascular Diseases
Fibrosis Antibodies	>120 publications with CXCL10 and Fibrosis
Neoplasms, Experimental Antibodies	>110 publications with CXCL10 and Neoplasms, Experimental
Kidney Diseases Antibodies	>80 publications with CXCL10 and Kidney Diseases
Lung Injury Antibodies	>60 publications with CXCL10 and Lung Injury

Organs/Tissues associated with CXCL10 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1900 publications with CXCL10 and Blood
Lung Antibodies	>428 publications with CXCL10 and Lung
Liver Antibodies	>249 publications with CXCL10 and Liver
Kidney Antibodies	>168 publications with CXCL10 and Kidney
Lymph Node Antibodies	>154 publications with CXCL10 and Lymph Node
Muscle Antibodies	>113 publications with CXCL10 and Muscle
Intestine Antibodies	>87 publications with CXCL10 and Intestine
Nerve Antibodies	>57 publications with CXCL10 and Nerve
Uterus Antibodies	>30 publications with CXCL10 and Uterus
Placenta Antibodies	>24 publications with CXCL10 and Placenta